Parmar Kanak, Subramanyam Sai, Del Rio-Pertuz Gaspar, Sethi Pooja, Argueta-Sosa Erwin
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
School of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore 560048, India.
Vaccines (Basel). 2022 Apr 29;10(5):700. doi: 10.3390/vaccines10050700.
The Vaccine Adverse Event Reporting System database has been used to report adverse events following several vaccines. We studied the patient population predisposed to such reactions and how these reactions differ with respect to the vaccine type. We searched the electronic databases PubMed, EMBASE, and Scopus up to 9 July 2021 for any study describing cardiac adverse events attributed to the vaccination. A total of 56 studies met the criteria comprising 340 patients. There were 20 studies describing cardiac adverse events following smallpox vaccination, 11 studies describing adverse events after influenza vaccination, and 18 studies describing adverse events after COVID-19 vaccination. There was a total of six studies describing cardiac adverse events after the pneumococcal vaccine, tetanus toxoid, cholera vaccine, and rabies vaccine. Adverse events following influenza vaccination occurred more commonly in older females within an average duration of four days from vaccination. Pericardial involvement was the most reported adverse event. Adverse events following COVID-19 vaccination happened at a mean age of 42.7 years, more commonly in males, and mostly after a second dose. Adverse events following smallpox vaccination occurred more commonly in younger males, with an average onset of symptoms from vaccination around 16.6 days. Adverse events were mostly myopericarditis; however, the acute coronary syndrome has been reported with some vaccines.
疫苗不良事件报告系统数据库已被用于报告多种疫苗接种后的不良事件。我们研究了易发生此类反应的患者群体，以及这些反应在疫苗类型方面的差异。我们检索了截至2021年7月9日的电子数据库PubMed、EMBASE和Scopus，以查找任何描述疫苗接种所致心脏不良事件的研究。共有56项研究符合标准，涉及340名患者。有20项研究描述了天花疫苗接种后的心脏不良事件，11项研究描述了流感疫苗接种后的不良事件，18项研究描述了新冠疫苗接种后的不良事件。共有6项研究描述了肺炎球菌疫苗、破伤风类毒素、霍乱疫苗和狂犬病疫苗接种后的心脏不良事件。流感疫苗接种后的不良事件在老年女性中更常见，平均发生在接种后四天内。心包受累是报告最多的不良事件。新冠疫苗接种后的不良事件发生的平均年龄为42.7岁，男性更常见，且大多发生在第二剂接种后。天花疫苗接种后的不良事件在年轻男性中更常见，接种后症状平均发作时间约为16.6天。不良事件大多为心肌心包炎；然而，也有一些疫苗报告了急性冠状动脉综合征。
