Clarke Michelle, Mathew Suja M, Giles Lynne C, Pena Alexia S, Barr Ian G, Richmond Peter C, Marshall Helen S
Women's and Children's Health Network, North Adelaide, SA 5006, Australia.
The Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia.
Vaccines (Basel). 2022 Apr 29;10(5):699. doi: 10.3390/vaccines10050699.
Obesity can increase the severity of influenza infection. Data are limited regarding immune responses to influenza vaccination in obese children. We aimed to investigate the impact of obesity on quadrivalent influenza vaccine responses in children. Children with obesity (body mass index (BMI) ≥ 95th percentile for age and gender) and children without obesity (BMI < 95th percentile) were enrolled in the study. Blood samples were collected before, 1, and 6 months after influenza vaccination, to measure antibody responses by haemagglutination inhibition (HI) assay. Vaccine immunogenicity outcomes were compared between children with and without obesity. Forty-four children (mean age 13.3 ± 2.1 years, 18 males and 14 with obesity) completed the 6-month study. More than 90% of the participants with and without obesity had seroprotective antibody titres (HI ≥ 40) at both 1 and 6 months following vaccination for each of the four influenza strains (A/H3N2, A/H1N1, B/(Victoria) and B/(Yamagata)). Influenza-specific geometric mean titres at baseline, 1, and 6 months post-vaccination were similar between children with and without obesity for all influenza vaccine strains. Children with and without obesity have robust, sustained antibody responses over 6 months to the quadrivalent influenza vaccine.
肥胖会增加流感感染的严重程度。关于肥胖儿童对流感疫苗免疫反应的数据有限。我们旨在研究肥胖对儿童四价流感疫苗反应的影响。肥胖儿童（体重指数（BMI）≥年龄和性别的第95百分位数）和非肥胖儿童（BMI<第95百分位数）被纳入研究。在流感疫苗接种前、接种后1个月和6个月采集血样，通过血凝抑制（HI）试验测量抗体反应。比较肥胖儿童和非肥胖儿童的疫苗免疫原性结果。44名儿童（平均年龄13.3±2.1岁，18名男性，14名肥胖）完成了为期6个月的研究。对于四种流感毒株（A/H3N2、A/H1N1、B/（维多利亚）和B/（山形））中的每一种，超过90%的肥胖和非肥胖参与者在接种疫苗后的1个月和6个月时都具有血清保护性抗体滴度（HI≥40）。对于所有流感疫苗毒株，肥胖儿童和非肥胖儿童在接种疫苗后基线、1个月和6个月时的流感特异性几何平均滴度相似。肥胖儿童和非肥胖儿童在6个月内对四价流感疫苗都有强烈、持续的抗体反应。
