Department of Pathology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Department of Liver Surgery, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Viruses. 2022 May 10;14(5):1017. doi: 10.3390/v14051017.
The Epstein-Barr virus (EBV) can cause different types of cancer in human beings when the virus infects different cell types with various latent patterns. EBV shapes a distinct and immunosuppressive tumor microenvironment (TME) to its benefit by influencing and interacting with different components in the TME. Different EBV-associated malignancies adopt similar but slightly specific immunosuppressive mechanisms by encoding different EBV products to escape both innate and adaptive immune responses. Strategies reversing the immunosuppressive TME of EBV-associated malignancies have been under evaluation in clinical practice. As the interactions among EBV, tumor cells, and TME are intricate, in this review, we mainly discuss the epidemiology of EBV, the life cycle of EBV, the cellular and molecular composition of TME, and a landscape of different EBV-associated malignancies and immunotherapy by targeting the TME.
当病毒以不同的潜伏模式感染不同的细胞类型时，爱泼斯坦-巴尔病毒（EBV）可导致人类罹患不同类型的癌症。EBV 通过影响和相互作用于肿瘤微环境（TME）中的不同成分，形成独特的免疫抑制性 TME，从而从中受益。不同的 EBV 相关恶性肿瘤通过编码不同的 EBV 产物来逃避固有和适应性免疫反应，从而采用类似但略有特异性的免疫抑制机制。在临床实践中，已经有针对 EBV 相关恶性肿瘤免疫抑制性 TME 的逆转策略正在评估中。由于 EBV、肿瘤细胞和 TME 之间的相互作用错综复杂，在这篇综述中，我们主要讨论了 EBV 的流行病学、EBV 的生命周期、TME 的细胞和分子组成，以及不同 EBV 相关恶性肿瘤和针对 TME 的免疫治疗的全景。
