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逆转录病毒 RNA 加工。

Retroviral RNA Processing.

机构信息

Biology Department, Johns Hopkins University, Baltimore, MD 21218, USA.

出版信息

Viruses. 2022 May 23;14(5):1113. doi: 10.3390/v14051113.

DOI:10.3390/v14051113
PMID:35632854
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9143442/
Abstract

This review is an accompaniment to a Special Issue on "Retroviral RNA Processing". It discusses post-transcriptional regulation of retroviruses, ranging from the ancient foamy viruses to more modern viruses, such as HIV-1, HTLV-1, Rous sarcoma virus, murine leukemia virus, mouse mammary tumor virus, and Mason-Pfizer monkey virus. This review is not comprehensive. However, it tries to address some of the major questions in the field with examples of how different retroviruses express their genes. It is amazing that a single primary RNA transcript can have so many possible fates: genomic RNA, unspliced mRNA, and up to 50 different alternatively spliced mRNAs. This review will discuss the sorting of RNAs for packaging or translation, RNA nuclear export mechanisms, splicing, translation, RNA modifications, and avoidance of nonsense-mediated RNA decay.

摘要

这篇综述是对“逆转录病毒 RNA 加工”特刊的补充。它讨论了从古老的泡沫病毒到更现代的病毒（如 HIV-1、HTLV-1、劳斯肉瘤病毒、鼠白血病病毒、鼠乳腺肿瘤病毒和 Mason-Pfizer 猴病毒）的逆转录病毒的转录后调控。这篇综述并不全面。然而，它试图用不同逆转录病毒表达基因的例子来解决该领域的一些主要问题。令人惊讶的是，单个初级 RNA 转录本可能有如此多的可能命运：基因组 RNA、未剪接的 mRNA，以及多达 50 种不同的选择性剪接的 mRNA。这篇综述将讨论 RNA 包装或翻译的分类、RNA 核输出机制、剪接、翻译、RNA 修饰以及避免无意义介导的 RNA 降解。

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