Amato Dahlia N, Amato Douglas V, Mavrodi Olga V, Martin William B, Swilley Sarah N, Parsons Keith H, Mavrodi Dmitri V, Patton Derek L
School of Polymers and High Performance Materials and §Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States.
School of Polymers and High Performance Materials and Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States.
ACS Macro Lett. 2017 Feb 21;6(2):171-175. doi: 10.1021/acsmacrolett.7b00009. Epub 2017 Feb 6.
We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAs derived from diallyl -chlorobenzaldehyde acetal degrade and release -chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAs enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.
我们描述了通过可降解缩醛（PANDAs）合成前抗菌网络，这是一种用于隔离和触发释放挥发性生物活性醛的新范例。源自二烯丙基 - 氯苯甲醛缩醛的PANDAs在温和条件下（pH 7.4/高湿度）降解并释放氯苯甲醛作为抗菌和抗真菌剂。我们表明，PANDAs能够轻松获得具有可调释放曲线、强效抗菌活性且不会引发抗菌抗性以及细胞毒性最小的材料。
