Chan Julian M W, Wojtecki Rudy J, Sardon Haritz, Lee Ashlynn L Z, Smith Cartney E, Shkumatov Artem, Gao Shujun, Kong Hyunjoon, Yang Yi Yan, Hedrick James L
IBM Almaden Research Center, 650 Harry Road, San Jose, California 95120, United States.
POLYMAT, University of the Basque Country UPV/EHU Joxe Mari Korta Center, Avda. Tolosa 72, 20018 Donostia-San Sebastián, Spain.
ACS Macro Lett. 2017 Feb 21;6(2):176-180. doi: 10.1021/acsmacrolett.6b00924. Epub 2017 Feb 7.
We report the design, synthesis, and evaluation of biodegradable amphiphilic poly(ethylene glycol)--polycarbonate-based diblock copolymers containing pendant persistent organic radicals (e.g., PROXYL). These paramagnetic radical-functionalized polymers self-assemble into micellar nanoparticles in aqueous media, which preferentially accumulate in tumor tissue via the enhanced permeability and retention (EPR) effect. Through relaxation NMR studies, as well as magnetic resonance imaging (MRI) studies on mice, we show that these nanomaterials are effective as metal-free, biodegradable MRI contrast agents. We also demonstrate anticancer drugs can be readily loaded into the nanoparticles, conferring therapeutic delivery properties in addition to their imaging properties making these materials potential theranostic agents in the treatment of cancer.
我们报告了含侧链持久性有机自由基（如PROXYL）的可生物降解两亲性聚乙二醇 - 聚碳酸酯基二嵌段共聚物的设计、合成及评估。这些顺磁自由基功能化聚合物在水性介质中自组装成胶束纳米颗粒，通过增强渗透和滞留（EPR）效应优先在肿瘤组织中积累。通过弛豫核磁共振研究以及对小鼠的磁共振成像（MRI）研究，我们表明这些纳米材料作为无金属、可生物降解的MRI造影剂是有效的。我们还证明抗癌药物可轻松负载到纳米颗粒中，赋予其除成像特性外的治疗递送特性，使这些材料成为癌症治疗中有潜力的诊疗剂。
