Hoang Thi Thai Thanh, Lee Jung Seok, Lee Yunki, Park Hyun Bong, Park Kyung Min, Park Ki Dong
Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Republic of Korea.
Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Korea.
ACS Macro Lett. 2017 Feb 21;6(2):83-88. doi: 10.1021/acsmacrolett.6b00841. Epub 2017 Jan 12.
A practical strategy to strengthen the inherent tissue adhesiveness of bioglues was investigated without compromising their chemical structure. A simple blending of α-cyclodextrins (α-CDs) in gelatin glues substantially improved the adhesiveness of the glues upon contact with porcine skin. Interestingly, the adhesiveness was even further enhanced when the glues were supplemented with γ-CDs through the formation of multivalent supramolecular networks inside of the glue. In contrast, the effect of β-CDs was rather limited because their water solubility is relatively low. A model study using modified gold substrates demonstrated that CDs also interacted with biomolecules naturally present in skin, thereby improving the adhesiveness. Altogether, we suggest that the supramolecular networking of CDs, both inside the glue and at the glue-skin interface, could reinforce tissue adhesiveness of bioglues, which allows them to be of great relevance to a primary treatment modality for larger skin incisions.
在不破坏生物胶水化学结构的前提下，研究了一种增强其固有组织粘附性的实用策略。在明胶胶水中简单混合α-环糊精（α-CDs），能显著提高胶水与猪皮接触时的粘附性。有趣的是，当通过在胶水中形成多价超分子网络向胶水中添加γ-CDs时，粘附性甚至会进一步增强。相比之下，β-CDs的效果相当有限，因为它们的水溶性相对较低。一项使用改性金基底的模型研究表明，环糊精还与皮肤中天然存在的生物分子相互作用，从而提高了粘附性。总之，我们认为环糊精在胶水内部以及胶水与皮肤界面处的超分子网络可以增强生物胶水的组织粘附性，这使得它们与较大皮肤切口的主要治疗方式密切相关。
