School of Energy & Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Nat Commun. 2022 Jan 10;13(1):112. doi: 10.1038/s41467-021-27659-w.
The quantification of supramolecular host-guest interactions is important for finely modulating supramolecular systems. Previously, most host-guest interactions quantified using force spectroscopic techniques have been reported in force units. However, accurately evaluating the adhesion energies of host-guest pairs remains challenging. Herein, using a surface forces apparatus, we directly quantify the interaction energies between cyclodextrin (CD)-modified surfaces and ditopic adamantane (DAd) molecules in water as a function of the DAd concentration and the CD cavity size. The adhesion energy of the β-CD-DAd complex drastically increased with increasing DAd concentration and reached saturation. Moreover, the molecular adhesion energy of a single host-guest inclusion complex was evaluated to be ~9.51 kT. This approach has potential for quantifying fundamental information toward furthering the understanding of supramolecular chemistry and its applications, such as molecular actuators, underwater adhesives, and biosensors, which require precise tuning of specific host-guest interactions.
超分子主客体相互作用的量化对于精细调节超分子体系非常重要。以前，使用力谱技术定量的大多数主客体相互作用都是以力单位报告的。然而，准确评估主客体对的粘附能仍然具有挑战性。在此，我们使用表面力仪直接定量测量了在水中环糊精（CD）修饰表面与双位金刚烷（DAd）分子之间的相互作用能作为 DAd 浓度和 CD 腔尺寸的函数。β-CD-DAd 配合物的粘附能随 DAd 浓度的增加而急剧增加，并达到饱和。此外，还评估了单个主客体包合物的分子粘附能约为 9.51 kT。这种方法有望定量提供基本信息，从而进一步理解超分子化学及其应用，例如分子致动器、水下粘合剂和生物传感器，这些应用需要精确调整特定的主客体相互作用。
