Department of Neurology, Tianjin Medical University Nankai Hospital, No. 6 Changjiang Road, Nankai District, Tianjin, 300100, China.
Department of Neurology, The First Affiliated Hospital of Jiamusi University, Jiamusi, 154002, China.
Acta Neurol Belg. 2022 Oct;122(5):1247-1259. doi: 10.1007/s13760-022-01973-6. Epub 2022 May 28.
Tea contains many polyphenols with biological properties such as antithrombosis and antioxidation. Recent observational studies on tea consumption concerning cerebral hemorrhage risk have reported inconsistent results. This meta-analysis aimed to summarize the accumulated evidence on the association between tea consumption and cerebral hemorrhage risk.
Web of Science, PubMed, Embase, and Scopus databases were searched to identify relevant studies through December 2021. Relative risks (RRs) or odds ratios (ORs) from observational studies were synthesized.
Ten studies involving over 721,827 participants were included. Higher tea consumption was correlated with a 23% (RR = 0.77; 95% CI 0.66-0.89) lower risk of cerebral hemorrhage. Subgroup meta-analyses indicated higher tea consumption was beneficial in preventing cerebral hemorrhage risk for green tea, alcohol-adjusted, fruit/vegetables-adjusted, and physical activity-adjusted subgroups, respectively (P < 0.01). Dose-response analysis indicated each one-cup (120 ml/cup) increment in tea or green tea intake/day was correlated with an average of 2% (RR = 0.98, 95% CI 0.976-0.990), or 6% (RR = 0.94; 95% CI 0.92-0.97) lower cerebral hemorrhage risk.
This study suggests that daily tea consumption is related to a lower risk of cerebral hemorrhage among adults. Green tea consumption appears to be more beneficial in preventing cerebral hemorrhage. Physical activity, fruit/vegetables, and alcohol may affect the relationship between tea consumption and hemorrhagic stroke. Future studies should investigate the interplay of tea with these factors.
茶含有多种具有抗血栓和抗氧化等生物特性的多酚。最近关于饮茶与脑出血风险的观察性研究报告结果不一致。本荟萃分析旨在总结关于饮茶与脑出血风险之间关联的现有证据。
通过 2021 年 12 月检索 Web of Science、PubMed、Embase 和 Scopus 数据库，以确定相关研究。综合观察性研究的相对风险（RR）或比值比（OR）。
纳入了 10 项涉及超过 721827 名参与者的研究。较高的茶摄入量与脑出血风险降低 23%（RR=0.77；95%CI 0.66-0.89）相关。亚组荟萃分析表明，对于绿茶、酒精调整、水果/蔬菜调整和体力活动调整亚组，较高的茶摄入量分别有利于预防脑出血风险（P<0.01）。剂量反应分析表明，每天每增加一杯（120ml/杯）茶或绿茶摄入量与脑出血风险平均降低 2%（RR=0.98，95%CI 0.976-0.990）或 6%（RR=0.94；95%CI 0.92-0.97）相关。
本研究表明，成年人每天饮茶与脑出血风险降低相关。饮用绿茶似乎更有利于预防脑出血。体力活动、水果/蔬菜和酒精可能会影响饮茶与出血性中风之间的关系。未来的研究应调查茶与这些因素的相互作用。
