1Department of Neurology,The First Affiliated Hospital of Jiamusi University,154002 Jiamusi,Heilongjiang Province,People's Republic of China.
2Department of Histology and Embryology,School of Basic Medical Sciences,Jiamusi University,154002 Jiamusi,Heilongjiang Province,People's Republic of China.
Br J Nutr. 2018 Nov;120(10):1181-1188. doi: 10.1017/S0007114518002647.
Findings from observational studies on the associations between vitamin E intake and stroke risk remain controversial, and the dose-response relationship between vitamin E intake and risk of stroke remains to be determined. We conducted a meta-analysis of prospective studies aiming to clarify the relationships between vitamin E intake and risk of stroke. Relevant studies were identified by searching online databases through to June 2018. We computed summary relative risks (RR) with corresponding 95 % CI. Among 3156 articles retrieved from online databases and relevant bibliographies, nine studies involving 3284 events and 220 371 participants were included in the final analyses. High dietary vitamin E intake was inversely associated with the risk of overall stroke (RR=0·83, 95 % CI 0·73, 0·94), and with the risk of stroke for individuals who were followed-up for <10 (RR=0·84, 95 % CI 0·72, 0·91). There was a non-linear association between dietary vitamin E intake and stroke risk (P=0·0249). Omission of any single study did not alter the summary result. In conclusion, this meta-analysis suggests that there is a significant inverse relationship between dietary vitamin E intake and stroke risk. This meta-analysis provides evidence that a higher dietary vitamin E intake is associated with a lower stroke risk.
观察性研究关于维生素 E 摄入与中风风险之间的关联的结果仍存在争议，维生素 E 摄入与中风风险之间的剂量反应关系仍有待确定。我们进行了一项荟萃分析，旨在阐明维生素 E 摄入与中风风险之间的关系。通过截至 2018 年 6 月在在线数据库中进行搜索，确定了相关研究。我们计算了汇总相对风险（RR）及其相应的 95 %置信区间。从在线数据库和相关文献中检索到的 3156 篇文章中，有 9 项研究涉及 3284 例事件和 220371 名参与者，最终纳入了分析。高膳食维生素 E 摄入与总体中风风险呈负相关（RR=0·83，95 % CI 0·73，0·94），与随访<10 年的个体中风风险呈负相关（RR=0·84，95 % CI 0·72，0·91）。膳食维生素 E 摄入与中风风险之间存在非线性关系（P=0·0249）。省略任何一项研究都不会改变汇总结果。总之，这项荟萃分析表明，膳食维生素 E 摄入与中风风险之间存在显著的负相关关系。这项荟萃分析提供了证据，表明较高的膳食维生素 E 摄入与较低的中风风险相关。
