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[霍顿病与肢根性假多关节炎。关于95例的发育数据]

[Horton's disease and rhizomelic pseudopolyarthritis. Developmental data apropos of 95 cases].

作者信息

Piton J L, Zagala A, Rebuffet J L, Reynes O, Reynes J F, Souteyrand P, Phelip X

出版信息

Rev Rhum Mal Osteoartic. 1987 Jan;54(1):7-13.

PMID:3563372
Abstract

The many common factors linking rhizomelic pseudopolyarthritis and Horton's disease prompt to compare their respective evolutions and the long-term results of their treatments. The comparative study of 28 patients with temporal Horton's arteritis, proven histologically, and 28 rhizomelic pseudopolyarthritis without arteritis on biopsy, in a total population of 95 patients, confirms the similarity of their clinical and biological signs and show a closely related evolution in the three groups. The evolution leads to a cure approximately 16.4 +/- 14 months in 41 p. cent of the cases. 34 p. cent of the patients are at an advanced stage with a mean follow-up of 37 months and relapses during the weaning period were frequent. 25 p. cent of the patients died. Most deaths occur in the first month of the disease, and occur readily in patients who have received a short treatment with steroids discontinued because of a iatrogenic accident. Cerebral vascular accidents and coronary accidents, arterial hypertension and iatrogenic gastro-intestinal ulcerations are the most frequent complications.

摘要

连接肢根性假多关节炎和霍顿病的诸多共同因素促使人们比较它们各自的病程以及治疗的长期效果。在总共95例患者中,对28例经组织学证实的颞部霍顿动脉炎患者和28例活检无动脉炎的肢根性假多关节炎患者进行的对比研究,证实了它们临床和生物学体征的相似性,并显示三组的病程密切相关。约41%的病例病程约16.4±14个月后治愈。34%的患者处于晚期,平均随访37个月,撤药期复发频繁。25%的患者死亡。大多数死亡发生在疾病的第一个月,且容易发生在因医源性事故而短期使用类固醇后停药的患者身上。脑血管意外和冠状动脉意外、动脉高血压和医源性胃肠道溃疡是最常见的并发症。

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