Pedersen J H, Sørensen T I, Andersen B, Stadil F
Scand J Gastroenterol. 1987 Jan;22(1):69-74. doi: 10.3109/00365528708991859.
The functional role of the jejunum and ileum with regard to peripheral plasma levels of intact neurotensin and NH2-terminal immunoreactivity of neurotensin was studied by using jejunoileal bypass as a model. Plasma levels were measured by radioimmunoassay before and after jejunoileal bypass randomized to different jejunoileal ratios. Seven patients were studied before bypass surgery and 28 were examined after end-to-side jejunoileal bypass with 50 cm intestine in continuity and a 3:1 or 1:3 ratio between the length of the jejunal and ileal segments. Fasting levels of intact neurotensin were unchanged by surgery, whereas levels of NH2-terminal immunoreactivity were higher in bypass patients with a long ileal segment (37.5 cm) than in unoperated patients and in those with a short ileal segment (12.5 cm). Meal-stimulated levels of intact neurotensin were higher after 1:3 than 3:1 jejunoileal bypass. The levels of NH2-terminal immunoreactivity in patients with a short ileal segment and in controls were lower than in patients with a long ileal segment. The results show that postprandial levels of both intact neurotensin and NH2-terminal immunoreactivity are related to the length of the functioning ileum and that even a difference in length of 25 cm is reflected in the circulating levels of neurotensin.
以空肠回肠旁路手术为模型，研究了空肠和回肠对外周血浆中完整神经降压素水平及神经降压素氨基末端免疫反应性的功能作用。通过放射免疫分析法在随机采用不同空肠回肠比例进行空肠回肠旁路手术前后测量血浆水平。7例患者在旁路手术前接受研究，28例患者在进行端侧空肠回肠旁路手术后接受检查，术中保留50 cm连续肠段，空肠段与回肠段长度比例为3:1或1:3。手术前后空腹时完整神经降压素水平未发生变化，然而，具有较长回肠段（37.5 cm）的旁路手术患者的氨基末端免疫反应性水平高于未手术患者及具有较短回肠段（12.5 cm）的患者。空肠回肠旁路比例为1:3时餐后完整神经降压素水平高于3:1时。具有较短回肠段的患者及对照组的氨基末端免疫反应性水平低于具有较长回肠段的患者。结果表明，餐后完整神经降压素和氨基末端免疫反应性水平均与发挥功能的回肠长度有关，即使25 cm的长度差异也会反映在神经降压素的循环水平上。
