Miskowiak J, Pedersen J H, Andersen B, Stadil F
Regul Pept. 1984 Nov;9(4):263-9. doi: 10.1016/0167-0115(84)90078-8.
Fasting and postprandial plasma levels of the tridecapeptide neurotensin were determined in ten women before and three months after gastroplasty for morbid obesity. Measurements were by radioimmunoassay in unextracted plasma with two antisera recognizing intact neurotensin (NT1-13) or intact neurotensin together with small C-terminal fragments, which may circulate as metabolites of neurotensin. Levels of both intact neurotensin and C-terminal immunoreactivity in obese women were in the same order of magnitude as those found previously in lean persons. Fasting levels measured with both antisera were significantly reduced following gastroplasty (P less than 0.01). Meal-stimulated levels and increments were unchanged. The cause of this prolonged reduction is at present unknown, but may be a reduced luminal stimulation of the small intestine or an altered vagal tonus following gastroplasty.
对10名病态肥胖女性在胃成形术前及术后3个月测定了十三肽神经降压素的空腹和餐后血浆水平。采用放射免疫分析法，使用两种抗血清在未提取的血浆中进行测量，一种抗血清识别完整的神经降压素（NT1 - 13），另一种抗血清识别完整的神经降压素以及小的C末端片段，这些小的C末端片段可能作为神经降压素的代谢产物在循环中存在。肥胖女性中完整神经降压素和C末端免疫反应性的水平与先前在瘦人身上发现的水平处于同一数量级。胃成形术后，两种抗血清测得的空腹水平均显著降低（P小于0.01）。进餐刺激后的水平及增加值未发生变化。这种持续降低的原因目前尚不清楚，但可能是胃成形术后小肠腔内刺激减少或迷走神经张力改变所致。
