Krogsgaard K, Christensen E, Gluud C, Henriksen J H, Christoffersen P
Scand J Gastroenterol. 1987 Jan;22(1):82-6. doi: 10.3109/00365528708991861.
In 46 alcoholic patients the association of wedged-to-free hepatic-vein pressure with other variables (clinical, histologic, hemodynamic, and liver function data) was studied by means of multiple regression analysis, taking the wedged-to-free hepatic-vein pressure as the dependent variable. Four variables showed significant independent association with the wedged-to-free hepatic-vein pressure: indocyanine green clearance (p = 0.031), degree of necrosis (p = 0.023), degree of hepatic architectural destruction (graded as: preserved architecture, nodules alternating with preserved architecture, totally destroyed architecture) (p = 2.3 X 10(-6) and sex (p = 0.0024), male sex being associated with higher wedged-to-free hepatic-vein pressure. The multiple coefficient of determination (R2) was 0.63; thus, 63% of the variation in the wedged-to-free hepatic-vein pressure was 'explained' by variation in these four variables.
在46例酒精性肝病患者中，以肝静脉楔压与自由压的比值作为因变量，通过多元回归分析研究其与其他变量（临床、组织学、血流动力学和肝功能数据）之间的关系。有四个变量与肝静脉楔压与自由压的比值呈现显著的独立相关性：吲哚菁绿清除率（p = 0.031）、坏死程度（p = 0.023）、肝结构破坏程度（分级为：结构保存、结节与保存结构交替、结构完全破坏）（p = 2.3×10⁻⁶）以及性别（p = 0.0024），男性与较高的肝静脉楔压与自由压比值相关。多元决定系数（R²）为0.63；因此，这四个变量的变化“解释”了肝静脉楔压与自由压比值63%的变异。
