Shimada M, Matsumata T, Itasaka H, Shirabe K, Taketomi A, Sugimachi K
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Surg Today. 1994;24(4):309-12. doi: 10.1007/BF02348558.
Portal pressures were estimated non-invasively in 100 patients who underwent hepatic resection and completely fulfilled the 21 variables evaluated. Ten variables were selected from among all those in the univariate analysis, and a stepwise discriminant analysis revealed four independent significant variables, namely: The indocyanine green dye retention test at 15 min (ICGR15); the prothrombin time index; the platelet count; and the globulin fraction. An equation to estimate the portal pressure was made using the coefficients in the analysis, the reliability of which was confirmed (r = 0.70484, P = 0.0001). The univariate analysis revealed ten significant variables to discriminate portal hypertension, defined as a portal pressure of over 200 mmH2O. A multiple logistic regression analysis of these variables revealed two independent variables, being ICGR15 and the platelet count. Thus, we consider that our equation for estimating portal pressure is potentially useful, and that the platelet count and ICGR15 are the most significant parameters in discriminating between the presence or absence of portal hypertension. Moreover, a platelet count of less than 120 x 10(3)/mm3 and an ICGR15 value of more than 15% correlated well with portal hypertension.
对100例行肝切除术且完全满足所评估的21项变量的患者进行了门静脉压力的无创估计。从单因素分析的所有变量中选择了10项变量，逐步判别分析显示了4个独立的显著变量，即：15分钟吲哚菁绿染料滞留试验（ICGR15）；凝血酶原时间指数；血小板计数；以及球蛋白组分。利用分析中的系数建立了一个估计门静脉压力的方程，其可靠性得到了证实（r = 0.70484，P = 0.0001）。单因素分析显示有10个显著变量可用于鉴别门静脉高压，门静脉高压定义为门静脉压力超过200 mmHg2O。对这些变量进行多元逻辑回归分析显示有2个独立变量，即ICGR15和血小板计数。因此，我们认为我们的门静脉压力估计方程可能有用，并且血小板计数和ICGR15是鉴别有无门静脉高压的最重要参数。此外，血小板计数低于120×10(3)/mm3和ICGR15值超过15%与门静脉高压密切相关。
