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Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial.纳武利尤单抗对比索拉非尼用于治疗晚期肝细胞癌（CheckMate 459）：一项随机、多中心、开放标签、III 期临床试验。
Lancet Oncol. 2022 Jan;23(1):77-90. doi: 10.1016/S1470-2045(21)00604-5. Epub 2021 Dec 13.
2
Impaired Response to Immunotherapy in Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma?非酒精性脂肪性肝炎相关肝细胞癌对免疫疗法的反应受损？
Liver Cancer. 2021 Jul;10(4):289-295. doi: 10.1159/000517841. Epub 2021 Jul 2.
3
Safety, Efficacy, and Pharmacodynamics of Tremelimumab Plus Durvalumab for Patients With Unresectable Hepatocellular Carcinoma: Randomized Expansion of a Phase I/II Study.替西木单抗联合度伐利尤单抗治疗不可切除肝细胞癌患者的安全性、疗效和药效学：一项 I/II 期研究的随机扩展。
J Clin Oncol. 2021 Sep 20;39(27):2991-3001. doi: 10.1200/JCO.20.03555. Epub 2021 Jul 22.
4
Limited Impact of Anti-PD-1/PD-L1 Monotherapy for Hepatocellular Carcinoma.抗PD-1/PD-L1单药疗法对肝细胞癌的疗效有限。
Liver Cancer. 2020 Dec;9(6):629-639. doi: 10.1159/000512170. Epub 2020 Oct 26.
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Gd-EOB-DTPA-MRI Could Predict WNT/β-Catenin Mutation and Resistance to Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma.钆塞酸二钠增强磁共振成像可预测肝细胞癌中WNT/β-连环蛋白突变及对免疫检查点抑制剂治疗的耐药性。
Liver Cancer. 2020 Sep;9(5):479-490. doi: 10.1159/000509554. Epub 2020 Aug 20.
6
Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib: The CheckMate 040 Randomized Clinical Trial.纳武利尤单抗联合伊匹木单抗治疗索拉非尼治疗后晚期肝细胞癌患者的疗效和安全性：CheckMate 040 随机临床试验。
JAMA Oncol. 2020 Nov 1;6(11):e204564. doi: 10.1001/jamaoncol.2020.4564. Epub 2020 Nov 12.
7
Phase Ib Study of Lenvatinib Plus Pembrolizumab in Patients With Unresectable Hepatocellular Carcinoma.仑伐替尼联合帕博利珠单抗治疗不可切除肝细胞癌的 Ib 期研究。
J Clin Oncol. 2020 Sep 10;38(26):2960-2970. doi: 10.1200/JCO.20.00808. Epub 2020 Jul 27.
8
Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma.阿替利珠单抗联合贝伐珠单抗治疗不可切除肝细胞癌。
N Engl J Med. 2020 May 14;382(20):1894-1905. doi: 10.1056/NEJMoa1915745.
9
A New Era in Systemic Therapy for Hepatocellular Carcinoma: Atezolizumab plus Bevacizumab Combination Therapy.肝细胞癌全身治疗的新时代：阿替利珠单抗联合贝伐珠单抗联合疗法。
Liver Cancer. 2020 Apr;9(2):119-137. doi: 10.1159/000505189. Epub 2020 Mar 5.
10
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody.通过 Fc 工程化抗 CTLA-4 抗体对肿瘤免疫中的人 Treg 和效应 T 细胞进行差异化控制。
Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):609-618. doi: 10.1073/pnas.1812186116. Epub 2018 Dec 26.

Durvalumab Plus Tremelimumab: A Novel Combination Immunotherapy for Unresectable Hepatocellular Carcinoma.

作者信息

Kudo Masatoshi

机构信息

Editor-in-Chief, Liver Cancer, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.

出版信息

Liver Cancer. 2022 Feb 18;11(2):87-93. doi: 10.1159/000523702. eCollection 2022 Apr.

DOI:10.1159/000523702
PMID:35634425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9109076/
Abstract
摘要