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益生菌组合对雪貂感染新型冠状病毒以及对人类免疫细胞反应的影响

The effect of the probiotic consortia on SARS-CoV-2 infection in ferrets and on human immune cell response .

作者信息

Lehtinen Markus J, Kumar Ritesh, Zabel Bryan, Mäkelä Sanna M, Nedveck Derek, Tang Peipei, Latvala Sinikka, Guery Sebastien, Budinoff Charles R

机构信息

Health & Biosciences, IFF, Kantvik 02460, Finland.

Health & Biosciences, IFF, Wilmington, DE 19803, USA.

出版信息

iScience. 2022 Jun 17;25(6):104445. doi: 10.1016/j.isci.2022.104445. Epub 2022 May 23.

DOI:10.1016/j.isci.2022.104445
PMID:35634575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9125999/
Abstract

Probiotics have been suggested as one solution to counter detrimental health effects by SARS-CoV-2; however, data so far is scarce. We tested the effect of two probiotic consortia, OL-1 and OL-2, against SARS-CoV-2 in ferrets and assessed their effect on cytokine production and transcriptome in a human monocyte-derived macrophage (Mf) and dendritic cell (DC) model. The results showed that the consortia significantly reduced the viral load, modulated immune response, and regulated viral receptor expression in ferrets compared to placebo. In the human Mf and DC model, OL-1 and OL-2-induced cytokine production and genes related to SARS-CoV-2 antiviral immunity. The study results indicate that probiotic stimulation of the ferret immune system leads to improved antiviral immunity against SARS-COV-2, and the genes and cytokines associated with anti-SARS-CoV-2 immunity are stimulated in human immune cells . The effect of the consortia against SARS-CoV-2 warrants further investigations in human clinical trials.

摘要

益生菌已被提议作为应对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）对健康产生有害影响的一种解决方案；然而，目前的数据很少。我们在雪貂中测试了两种益生菌组合OL-1和OL-2对SARS-CoV-2的作用，并在人单核细胞衍生巨噬细胞（Mf）和树突状细胞（DC）模型中评估了它们对细胞因子产生和转录组的影响。结果表明，与安慰剂相比，这些组合显著降低了雪貂的病毒载量，调节了免疫反应，并调节了病毒受体表达。在人Mf和DC模型中，OL-1和OL-2诱导了与SARS-CoV-2抗病毒免疫相关的细胞因子产生和基因表达。研究结果表明，益生菌刺激雪貂免疫系统可提高对SARS-CoV-2的抗病毒免疫力，并且在人类免疫细胞中与抗SARS-CoV-2免疫相关的基因和细胞因子受到刺激。这些组合对SARS-CoV-2的作用值得在人类临床试验中进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/7e6d38a95b7c/gr8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/7e6d38a95b7c/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/ed582842db12/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/7d4995cb3240/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/3c3bd2a95c47/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/f608cbf27a22/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/18e7fdbc711d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/36b083cb84aa/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/d1201a4038a2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/afa75f951c01/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4967/9189133/7e6d38a95b7c/gr8.jpg

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