卡铂联合紫杉醇腹腔热灌注化疗对晚期复发性卵巢癌患者血清HE4和DJ-1水平的影响

Effects of carboplatin combined with paclitaxel-based intraperitoneal hyperthermic perfusion chemotherapy on serum levels of HE4 and DJ-1 in patients with advanced recurrent ovarian cancer.

作者信息

Su Xianhui, Sun Xuewen, Kang Yanhui, Dai Yuna

机构信息

Xianhui Su, Department of Pharmacology, Medical College of Hebei Engineering University, Handan, 056038, Hebei, China.

Xuewen Sun, Department of Pathogenic Biology, Medical College of Hebei Engineering University, Handan, 056038, Hebei, China.

出版信息

Pak J Med Sci. 2022 Mar-Apr;38(4Part-II):872-877. doi: 10.12669/pjms.38.4.4736.

DOI:10.12669/pjms.38.4.4736

PMID:35634603

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9121957/

Abstract

OBJECTIVE

To analyze the effects of carboplatin combined with paclitaxel-based intraperitoneal hyperthermic perfusion chemotherapy (IPCH) on serum levels of human epididymis protein 4 (HE4) and mitogen-dependent oncogene-1 (DJ-1) in patients with advanced recurrent ovarian cancer (OC).

METHODS

From July 2019 to July 2020, patients with advanced recurrent OC (n=92) treated in Affiliated Hospital of Hebei Engineering University were selected as study subjects. According to the random number table method, patients were divided into control group and observation group. Patients in the control group were treated with carboplatin combined with paclitaxel-based intravenous chemotherapy, and patients in the observation group were treated with carboplatin combined with paclitaxel-based IPCH. The therapeutic effects, serum levels of HE4, DJ-1 and human kallikrein 10 (HK-10), peripheral blood immune indexes and adverse reactions of patients were compared between the two groups.

RESULTS

The response rate of the observation group was significantly higher than that of the control group (0.05); after treatment, the indexes of HE4, DJ-1 and HK-10 in the two groups were significantly decreased, while the indexes of CD3CD4, CD3CD56 and CD3CD4/CD3CD8 were significantly increased; moreover, significantly lower indexes of HE4, DJ-1 and HK-10 and significantly higher indexes of CD3CD4, CD3CD56 and CD3CD4/CD3CD8 were found in the observation group when compared with the control group (<0.05). The severity of myelosuppression, nausea and vomiting in the observation group was significantly lower than that in the control group, and the total tumor metastasis rate in the observation group was significantly lower than that in the control group (0.05).

CONCLUSIONS

Carboplatin combined with paclitaxel IPCH had obvious inhibitory effects on HE4, DJ-1 and other serum tumor markers in patients with advanced recurrent OC, with a more prominent clinical effect, and could further significantly reduce the risk of adverse reactions and metastasis.

摘要

目的

分析卡铂联合紫杉醇腹腔热灌注化疗（IPCH）对晚期复发性卵巢癌（OC）患者血清人附睾蛋白4（HE4）和丝裂原依赖性癌基因1（DJ-1）水平的影响。

方法

选取2019年7月至2020年7月在河北工程大学附属医院接受治疗的晚期复发性OC患者（n = 92）作为研究对象。根据随机数字表法，将患者分为对照组和观察组。对照组患者接受卡铂联合紫杉醇静脉化疗，观察组患者接受卡铂联合紫杉醇IPCH治疗。比较两组患者的治疗效果、血清HE4、DJ-1和人激肽释放酶10（HK-10）水平、外周血免疫指标及不良反应。

结果

观察组的缓解率显著高于对照组（P<0.05）；治疗后，两组患者的HE4、DJ-1和HK-10指标均显著降低，而CD3CD4、CD3CD56和CD3CD4/CD3CD8指标均显著升高；此外，与对照组相比，观察组患者的HE4、DJ-1和HK-10指标显著更低，而CD3CD4、CD3CD56和CD3CD4/CD3CD8指标显著更高（P<0.05）。观察组患者的骨髓抑制、恶心呕吐严重程度显著低于对照组，观察组的总肿瘤转移率显著低于对照组（P<0.05）。