Belch J J, Drury J, McLaughlin K, O'Dowd A, Anderson J, Sturrock R D, Forbes C D
Scott Med J. 1987 Feb;32(1):12-4. doi: 10.1177/003693308703200106.
Finger blood flow is decreased in Raynauds Phenomenon (RP). This may be due not only to vasospasm, but also to blood abnormalities. 40 patients with Raynauds Disease (RD), 28 with suspected RP (SS) and 42 with secondary Raynauds syndrome (RS) were enrolled and compared to 50 controls. Results from base-line samples show that those with RP have abnormal haemostasis and rheology whereas those with mild Raynauds, RD do not. Blood sampled after cold challenge in 15 RS patients and 15 controls show that both groups exhibit platelet activation after emersion. The degree of activation however was much more marked in the RS patients. We have shown that abnormalities of haemostasis and rheology are found in patients likely to have endothelial damage (RS). These changes are probably a consequence rather than a cause of the disease. After cold challenge the results become more abnormal and correlate with severity of disease.
雷诺现象（RP）患者的手指血流量会减少。这可能不仅是由于血管痉挛，还与血液异常有关。招募了40例雷诺病（RD）患者、28例疑似RP患者（SS）和42例继发性雷诺综合征（RS）患者，并与50名对照者进行比较。基线样本结果显示，RP患者存在止血和流变学异常，而轻度雷诺病（RD）患者则没有。对15例RS患者和15名对照者进行冷刺激后采集的血液样本显示，两组在恢复后均出现血小板活化。然而，RS患者的活化程度更为明显。我们已经表明，在可能存在内皮损伤的患者（RS）中发现了止血和流变学异常。这些变化可能是疾病的结果而非病因。冷刺激后结果变得更加异常，且与疾病严重程度相关。
