Department of Dentistry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
J Clin Periodontol. 2022 Oct;49(10):970-979. doi: 10.1111/jcpe.13670. Epub 2022 Jun 17.
Tinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using Taiwan's National Health Insurance Research Database.
Among the 79,456 patients who visited for dental concerns, 11,055 patients who were diagnosed with periodontitis and underwent periodontal treatment between 2000 and 2015 were enrolled in Group 1. After matching for sex, age, and index year, 11,055 patients with periodontitis who received no treatment were enrolled in Group 2. Similarly, 11,055 participants without periodontitis were included as controls.
At the end of the follow-up, 412 and 404 participants in the two periodontitis groups and 321 participants in the control group had tinnitus. Cumulative risk for tinnitus in Group 1 or 2 was significantly greater than in the control group. More periodontitis patients than controls developed tinnitus (adjusted hazard ratios were 1.71 (95% confidence interval [CI]: 1.49-1.97, p < .001) and 1.64 (95% CI: 1.37-1.86, p < .001) in Groups 1 and 2, respectively). The risks were not significantly different between Groups 1 and 2. Similar findings were obtained after excluding data for the first 1 or 5 years.
The study findings indicate that periodontitis is associated with tinnitus.
耳鸣，即耳内鸣响，据推测是由炎症引起的。本研究使用台湾全民健康保险研究数据库，探讨牙周炎是否是耳鸣的一个风险因素。
在 79456 名因牙科问题就诊的患者中，纳入了 11055 名在 2000 年至 2015 年间被诊断为牙周炎并接受牙周治疗的患者，归入组 1。对性别、年龄和索引年进行匹配后，纳入了 11055 名未接受治疗的患有牙周炎的患者，归入组 2。同样，纳入了 11055 名无牙周炎的参与者作为对照组。
在随访结束时，两组牙周炎组的 412 名和 404 名参与者以及对照组的 321 名参与者出现了耳鸣。组 1 或 2 中耳鸣的累积风险明显高于对照组。与对照组相比，更多的牙周炎患者出现了耳鸣（调整后的风险比分别为 1.71（95%置信区间[CI]：1.49-1.97，p<0.001）和 1.64（95% CI：1.37-1.86，p<0.001））。组 1 和 2 之间的风险无显著差异。在排除前 1 年或前 5 年的数据后，也得到了相似的结果。
研究结果表明，牙周炎与耳鸣有关。
