Division of cardiology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
J Clin Periodontol. 2021 Aug;48(8):1085-1092. doi: 10.1111/jcpe.13478. Epub 2021 Jun 1.
Periodontitis and valvular heart disease (VHD) are common diseases. Both diseases are related to chronic inflammation and share many common risk factors. Previous periodontal studies had focused mainly on atherosclerotic cardiovascular disease. This study aimed to determine whether periodontitis is associated with the development of VHD.
This was a retrospective nationwide cohort study using Taiwan's Longitudinal Health Insurance Database. Using ICD-9-CM coding, both the periodontitis and non-periodontitis groups were matched.
There were 8483 cases and 4919 cases of VHD diagnosed in the periodontitis group and non-periodontitis group, respectively. The cumulative incidence of VHD was significantly higher in the periodontitis group (log-rank test, p < .001), with the incidence density of 6.44 (95% CI, 6.31-6.58) per 1000 person-years in the periodontitis group compared to 4.65 (95% CI, 4.52-4.78) in the non-periodontitis group. The relative risk for VHD was 1.39 (95% CI, 1.34-1.44). After multivariate analysis, periodontitis was independently associated with a risk for VHD (HR, 1.38; 95% CI, 1.33-1.42, p < .001). Intensive treatment of periodontitis significantly lowered the risk for VHD (HR, 0.68; 95% CI, 0.60-0.77, p < .001).
Periodontitis was significantly associated with the development of VHD. Treatment of periodontitis reduced the risk for VHD.
牙周炎和心脏瓣膜病（VHD）是常见疾病。这两种疾病都与慢性炎症有关，且有许多共同的危险因素。以前的牙周研究主要集中在动脉粥样硬化性心血管疾病上。本研究旨在确定牙周炎是否与 VHD 的发生有关。
这是一项使用台湾全民健康保险研究数据库的回顾性全国队列研究。使用 ICD-9-CM 编码，将牙周炎组和非牙周炎组进行匹配。
牙周炎组和非牙周炎组分别有 8483 例和 4919 例被诊断为 VHD。牙周炎组 VHD 的累积发生率明显较高（对数秩检验，p<0.001），牙周炎组的发病率密度为 6.44（95%CI，6.31-6.58）/1000 人年，而非牙周炎组为 4.65（95%CI，4.52-4.78）/1000 人年。VHD 的相对风险为 1.39（95%CI，1.34-1.44）。多变量分析后，牙周炎与 VHD 的发生风险独立相关（HR，1.38；95%CI，1.33-1.42，p<0.001）。牙周炎的强化治疗显著降低了 VHD 的发病风险（HR，0.68；95%CI，0.60-0.77，p<0.001）。
牙周炎与 VHD 的发生显著相关。牙周炎的治疗降低了 VHD 的发病风险。
