School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.
Expert Opin Drug Saf. 2022 Aug;21(8):1047-1060. doi: 10.1080/14740338.2022.2084071. Epub 2022 Jun 2.
Older people in residential aged care facilities (RACFs) have a high risk of safety issues and concerns about the potential quality of care received. This narrative review investigates the types of actual drug-related harms, their prevalence, reporting of any standard definitions for these harms, and their identification methods.
The authors conducted a systematic search on Ovid Embase, Ovid Medline, and PubMed from March 2001 to March 2021. This narrative review included all types of studies targeting aged care residents aged 65 years and above with actual drug-related harms.
The prevalence of actual drug-related harms in residents ranged from 0.07% to 63.0%. Falls, drug-drug interactions, neuropsychiatric symptoms, anaphylaxis, urinary tract infection, hypoglycemia, hypokalaemia, and acute kidney injury are the most common drug-related harms in older residents. Psychotropic drugs are the most common drug class implicated in these harms. Evidence related to the association between individual psychotropic drugs and injury, or harm is also lacking. Due to the variation in study duration, reported prevalence, identification methods, and absence of a definition for actual drug-related harms in most studies, further research is mandated to understand the prevalence and clinical implications of drug-related harms in older residents.
居住在养老院（RACFs）的老年人存在较高的安全问题风险，并且对所接受的潜在护理质量表示担忧。本叙事性综述研究了实际药物相关伤害的类型、其流行程度、对任何这些伤害的标准定义的报告以及它们的识别方法。
作者于 2001 年 3 月至 2021 年 3 月期间在 Ovid Embase、Ovid Medline 和 PubMed 上进行了系统检索。本叙事性综述包括所有针对 65 岁及以上养老院居民的实际药物相关伤害的研究类型。
居民中实际药物相关伤害的流行率从 0.07%到 63.0%不等。在老年居民中，最常见的药物相关伤害是跌倒、药物相互作用、神经精神症状、过敏反应、尿路感染、低血糖、低钾血症和急性肾损伤。精神药物是最常见的与这些伤害有关的药物类别。也缺乏与个别精神药物与伤害或伤害之间的关联相关的证据。由于研究持续时间、报告的流行率、识别方法以及大多数研究中缺乏实际药物相关伤害的定义存在差异，因此需要进一步研究以了解老年居民中药物相关伤害的流行程度和临床意义。
