Hara Yuki, Yamaguchi Rin, Yano Hiroshi, Iwasaki Keisuke
Department of Breast Surgery, Sasebo City General Hospital, Sasebo, Nagasaki, Japan.
Department of Pathology and Laboratory Medicine, Kurume University Medical Center, Kurume, Fukuoka, Japan.
Int J Surg Pathol. 2023 Jun;31(4):460-463. doi: 10.1177/10668969221102548. Epub 2022 May 29.
We present a rare tumor of adenoid cystic carcinoma, solid-basaloid subtype of the breast. Solid-basaloid adenoid cystic carcinoma may have a worse prognosis than classical adenoid cystic carcinoma. A 70-year-old woman presented with a mass in her left breast. Malignancy was suspected on imaging and confirmed via core needle biopsy. Left breast partial mastectomy and sentinel lymph node biopsy were performed. Histologically, the tumor was composed of basaloid cells with hyperchromatic nuclei and frequent mitotic figures, as are small-cell neuroendocrine carcinomas. Immunohistochemical analysis of the tumor cells showed high expression of KIT and CD10 and focal expression of keratin 7. Synaptophysin, chromogranin A, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 were not expressed. This patient should be followed up carefully for distant metastases and recurrences.
我们报告了一例罕见的乳腺腺样囊性癌实性基底样亚型肿瘤。实性基底样腺样囊性癌的预后可能比经典腺样囊性癌更差。一名70岁女性因左乳肿块就诊。影像学检查怀疑为恶性肿瘤，并通过粗针活检得以确诊。遂行左乳部分乳房切除术及前哨淋巴结活检。组织学上，肿瘤由具有核深染和频繁有丝分裂象的基底样细胞组成，小细胞神经内分泌癌也如此。肿瘤细胞的免疫组化分析显示KIT和CD10高表达，角蛋白7局灶性表达。突触素、嗜铬粒蛋白A、雌激素受体、孕激素受体和人表皮生长因子受体2均未表达。该患者应密切随访有无远处转移和复发情况。
