Department of Breast Surgery, Centro di riferimento oncologico della Basilicata (IRCCS-CROB), 85028, Rionero in Vulture (PZ), Italy.
Head of Multidisciplinary Oncology Unit, Centro di riferimento oncologico della Basilicata (IRCCS-CROB), 85028, Rionero in Vulture (PZ), Italy.
Future Oncol. 2022 Mar;18(7):871-881. doi: 10.2217/fon-2021-0860. Epub 2021 Dec 14.
Adenoid cystic carcinoma (ACC) of the breast is a very rare neoplasm. It presents a triple-negative phenotype in most cases, but its prognosis is generally considered to be better than other breast cancers with the same immunohistochemical pattern. Due to its controversial features, no data are available in the literature regarding a consensus approach for ACC treatment, especially for subtypes with worse prognosis like solid basaloid ACC. We present for the first time a rare case of ACC with multifocal presentation treated with breast-conservative surgery and intraoperative electron radiotherapy, thus supporting this treatment of ACC in selected patients like young women affected by the solid basaloid variant who commonly present a worse prognosis. In this case, no local or systemic recurrence was detected after 30 months of follow-up.
乳腺腺样囊性癌（ACC）是一种非常罕见的肿瘤。在大多数情况下，它表现为三阴性表型，但与具有相同免疫组织化学表型的其他乳腺癌相比，其预后通常被认为更好。由于其具有争议性的特征，文献中尚无关于 ACC 治疗共识方法的数据，特别是对于预后较差的实性基底样型 ACC 等亚型。我们首次报道了一例罕见的多灶性 ACC 病例，采用保乳手术和术中电子放射治疗，这支持了在某些患者中采用这种方法治疗 ACC，如年轻女性中常见的实性基底样型变体，此类患者的预后通常较差。在本病例中，经过 30 个月的随访，未发现局部或全身复发。
