Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China.
Australas J Dermatol. 2022 Aug;63(3):e200-e205. doi: 10.1111/ajd.13884. Epub 2022 May 30.
The pathogenesis of livedoid vasculopathy (LV) remains unknown. Although platelet activation occurs in LV, little research has been conducted on LV platelet morphology parameters. The purpose of this study was to investigate whether platelet morphology changes in LV and its clinical significance.
Twenty-seven LV patients and 21 cutaneous small vessel vasculitis (CSVV) patients, all at the active stage, were included. Platelet parameters in active- and stable-stage LV and CSVV patients were compared. Correlations between these platelet parameters and LV composite clinical scores were analysed.
LV patients' mean age was 25.48 years (range: 9-62 years), and 81.48% (22/27) were women and 18.52% (5/27) were men. The platelet counts and plateletcrit (PCT) levels were significantly elevated in LV patients compared with CSVV patients and in active-stage LV patients compared with stable-stage LV patients after treatment. LV patient composite clinical scores that reflected disease severity and activity were positively correlated with the platelet count and PCT levels.
Altered platelet morphology was detected in LV patients. Platelet count and PCT might be haematological biomarkers for early prediction of LV activity and relapses and for differential identification between LV and CSVV.
皮肤白细胞碎裂性血管炎（LV）的发病机制尚不清楚。尽管 LV 中存在血小板活化，但对 LV 血小板形态参数的研究甚少。本研究旨在探讨 LV 血小板形态变化及其临床意义。
纳入 27 例 LV 患者和 21 例皮肤小血管血管炎（CSVV）患者，均处于活动期。比较 LV 活动期和稳定期患者及 CSVV 患者的血小板参数。分析这些血小板参数与 LV 综合临床评分之间的相关性。
LV 患者的平均年龄为 25.48 岁（范围：9-62 岁），81.48%（22/27）为女性，18.52%（5/27）为男性。与 CSVV 患者相比，LV 患者的血小板计数和血小板压积（PCT）水平明显升高，且与治疗后活动期 LV 患者相比，稳定期 LV 患者的血小板计数和 PCT 水平也明显升高。反映疾病严重程度和活动度的 LV 患者综合临床评分与血小板计数和 PCT 水平呈正相关。
LV 患者存在血小板形态改变。血小板计数和 PCT 可能是 LV 活动和复发的早期预测以及 LV 与 CSVV 鉴别诊断的血液学标志物。
