Stanford University School of Medicine, Stanford, CA, 94305, USA.
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
J Psychiatr Res. 2022 Jul;151:583-589. doi: 10.1016/j.jpsychires.2022.05.018. Epub 2022 May 23.
Insulin resistance (IR) is linked to depressive disorders, and there is growing evidence that targeting IR may be beneficial in treating them. We examine the association between depressive symptoms and a direct measure of IR, and whether family history of type 2 diabetes (FHx-T2DM) or major depressive disorder (FHx-MDD) moderate this relationship.
Cross-sectional data were collected from 96 primarily overweight/obese adults ages 25-50 without diabetes or clinical depression. Multiple regression and correlation analyses were used to assess the association between depressive symptoms and a direct measure of IR (steady-state plasma glucose) as well as moderating effects of FHx-T2DM or FHx-MDD.
In the total sample, elevated depressive symptoms were positively associated with IR (p = 0.005). IR was associated with depressive symptoms in subjects with FHx-T2DM (p = 0.002) or FHx-MDD (p = 0.009) whereas BMI was associated with depressive symptoms in subjects without FHx-T2DM (p = 0.049) or FHx-MDD (p = 0.029). The odds of being in the top tertile of IR increased with elevated depressive symptoms alone (OR, 4.22; 95%CI, 1.15 to 17.33), presence of FHx-T2DM alone (OR, 3.42; 95%CI, 1.26 to 10.00), and presence of both FHx-T2DM and elevated depressive symptoms (OR, 10.08; 95%CI, 1.94 to 96.96).
Our findings indicate that depressive symptoms are positively associated with a direct measure of IR in overweight/obese individuals without diabetes or clinical depression. This association is moderated by FHx-T2DM. Early identification of groups vulnerable to IR related to depressive symptomatology may be useful for determining personalized interventions that have the potential to reduce morbidity in later years.
胰岛素抵抗（IR）与抑郁障碍有关，越来越多的证据表明，针对 IR 可能对治疗这些疾病有益。我们研究了抑郁症状与 IR 的直接测量指标之间的关系，以及 2 型糖尿病家族史（FHx-T2DM）或重度抑郁症家族史（FHx-MDD）是否会调节这种关系。
从 96 名年龄在 25-50 岁、超重/肥胖且无糖尿病或临床抑郁的成年人中收集横断面数据。采用多元回归和相关分析评估抑郁症状与 IR 的直接测量指标（稳态血浆葡萄糖）之间的关系，以及 FHx-T2DM 或 FHx-MDD 的调节作用。
在总样本中，抑郁症状升高与 IR 呈正相关（p=0.005）。在有 FHx-T2DM 或 FHx-MDD 的受试者中，IR 与抑郁症状相关（p=0.002 或 p=0.009），而在无 FHx-T2DM 或 FHx-MDD 的受试者中，BMI 与抑郁症状相关（p=0.049 或 p=0.029）。仅抑郁症状升高，IR 处于最高三分位的可能性增加（OR，4.22；95%CI，1.15 至 17.33），仅存在 FHx-T2DM（OR，3.42；95%CI，1.26 至 10.00），以及同时存在 FHx-T2DM 和抑郁症状升高（OR，10.08；95%CI，1.94 至 96.96）。
我们的发现表明，在无糖尿病或临床抑郁的超重/肥胖个体中，抑郁症状与 IR 的直接测量指标呈正相关。这种关联受 FHx-T2DM 的调节。早期识别易患与抑郁症状相关的 IR 的人群，可能有助于确定个性化干预措施，从而降低日后发病的可能性。
