Ohene-Agyei Phyllis, Gamble Greg D, Tran Thach, Harding Jane E, Crowther Caroline A
Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand.
School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia.
Arch Womens Ment Health. 2025 Aug;28(4):819-830. doi: 10.1007/s00737-024-01551-0. Epub 2025 Jan 15.
There is limited high-quality evidence about perinatal mental health among women with gestational diabetes. We aimed to assess the risks and longitudinal changes in anxiety, depression, and health-related quality of life comparing women with gestational diabetes and those without among a contemporary cohort of pregnant women.
Prospective cohort study of participants in the GEMS Trial. Women with a singleton pregnancy were eligible if they had a 75-g diagnostic oral glucose-tolerance test between 24 and 32 weeks' gestation, provided written informed consent, and completed questionnaires about anxiety, depression, and health-related quality of life at the study time points.
There were no differences in risk for anxiety (RR 1.13, 95% CI 0.86, 1.49; p = 0.39) or depression (RR 1.08, 95% CI 0.78, 1.50; p = 0.64) between the two groups at 36 weeks' gestation or 6 months postpartum [anxiety: (RR 1.21, 95% CI 0.90, 1.63; p = 0.21); depression: (RR 0.84, 95% CI 0.55, 1.28; p = 0.43]. However, at 36 weeks' gestation participants with gestational diabetes reported better physical functioning, and at 6 months postpartum, better mental functioning (mean difference (MD) in scores 1.28, 95% CI 0.25, 2.30; p = 0.01) although worse physical functioning (MD -2.99, 95% CI -3.90, -2.07; p = < 0.001) compared to participants without.
The risk for poor mental health during the perinatal period does not differ importantly among women diagnosed and treated for gestational diabetes compared to the general pregnant population.
关于妊娠期糖尿病女性围产期心理健康的高质量证据有限。我们旨在评估当代孕妇队列中患有妊娠期糖尿病和未患妊娠期糖尿病的女性在焦虑、抑郁及健康相关生活质量方面的风险和纵向变化。
对参与GEMS试验的参与者进行前瞻性队列研究。单胎妊娠的女性若在妊娠24至32周期间进行了75克诊断性口服葡萄糖耐量试验、提供了书面知情同意书并在研究时间点完成了关于焦虑、抑郁及健康相关生活质量的问卷调查，则符合条件。
在妊娠36周或产后6个月时，两组之间在焦虑风险（风险比1.13，95%置信区间0.86，1.49；p = 0.39）或抑郁风险（风险比1.08，95%置信区间0.78，1.50；p = 0.64）方面无差异[焦虑：（风险比1.21，95%置信区间0.90，1.63；p = 0.21）；抑郁：（风险比0.84，95%置信区间0.55，1.28；p = 0.43）]。然而，在妊娠36周时，患有妊娠期糖尿病的参与者报告身体功能更好，在产后6个月时，心理功能更好（得分平均差异（MD）为1.28，95%置信区间0.25，2.30；p = 0.01），尽管与未患妊娠期糖尿病的参与者相比，身体功能更差（MD -2.99，95%置信区间 -3.90，-2.07；p < 0.001）。
与一般孕妇群体相比，被诊断和治疗妊娠期糖尿病的女性在围产期心理健康不良的风险没有显著差异。
