Department of Biotechnology and Genetic Engineering, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid 22110, Jordan.
Department of Biotechnology and Genetic Engineering, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid 22110, Jordan.
Cell Immunol. 2022 Jul;377:104554. doi: 10.1016/j.cellimm.2022.104554. Epub 2022 May 26.
T-cell-mediated immune responses play indispensable roles in the defense against infectious pathogens including human immunodeficiency virus type 1 (HIV-1) which can establish a persistent infection that leads to many alterations in T-cell-mediated immunity. The latter include T-cell hyperactivation and depletion, both of which are essential for disease progression. Determining the factors and mechanisms pathways that lead to such abnormalities in T-cell mediated immunity during HIV-1 infection and ascertaining how the virus is able to evade immune responses elicited by T cells are critical for understanding the pathophysiology of HIV-1 infection, which in turn, could lead to new insights that may accelerate the development of novel and effective therapeutic strategies. To this end, we addressed the roles played by HIV-1 Tat protein, one of the first proteins to be expressed, in the pathogenesis of HIV-1 infection, focusing on the pathological effects of this protein in the cellular adaptive immune response in which T cells are intimately involved.
T 细胞介导的免疫反应在抵御感染性病原体（包括人类免疫缺陷病毒 1 型，即 HIV-1）中发挥着不可或缺的作用，HIV-1 可建立持续性感染，导致 T 细胞介导的免疫发生许多改变。后者包括 T 细胞的过度激活和耗竭，这两者对于疾病进展都是至关重要的。确定导致 HIV-1 感染期间 T 细胞介导免疫异常的因素和机制途径，并确定病毒如何逃避 T 细胞引发的免疫反应，对于理解 HIV-1 感染的病理生理学至关重要，而这反过来又可能为新的有效的治疗策略的开发提供新的见解。为此，我们研究了 HIV-1 Tat 蛋白在 HIV-1 感染发病机制中的作用，该蛋白是最早表达的蛋白之一，重点研究了该蛋白在 T 细胞密切参与的细胞适应性免疫反应中的病理作用。
