Amity School of Applied Sciences Lucknow, Amity University Uttar Pradesh, Lucknow Campus, India.
Amity Institute of Biotechnology, Amity University, Chhattisgarh, India.
Drug Res (Stuttg). 2022 Sep;72(7):355-366. doi: 10.1055/a-1824-4619. Epub 2022 May 30.
The rapid advancement of nanomedicine presents novel alternatives that have the potential to transform health care. Targeted drug delivery as well as the synthesis of nanocarriers is a growing discipline that has been intensively researched to reduce the complexity of present medicines in a variety of diseases and to develop new treatment and diagnostic techniques. There are several designed nanomaterials used as a delivery system such as liposomes, micelles, dendrimers, polymers, carbon-based materials, and many other substances, which deliver the drug moiety directly into its targeted body area reducing toxic effect of conventional drug delivery, thus reducing the amount of drug required for therapeutic efficacy and offering many more advantages. Currently, these are used in many applications, including cancer treatment, imaging contrast agents, and biomarker detection and so on. This review provides a comprehensive update in the field of targeted nano-based drug delivery systems, by conducting a thorough examination of the drug synthesis, types, targets, and application of nanomedicines in improving the therapeutic efficiency.
纳米医学的快速发展带来了新的选择，有可能改变医疗保健方式。靶向药物输送以及纳米载体的合成是一个不断发展的学科，已经进行了深入研究，以降低各种疾病中现有药物的复杂性，并开发新的治疗和诊断技术。有几种设计的纳米材料被用作输送系统，如脂质体、胶束、树枝状聚合物、聚合物、碳基材料和许多其他物质，它们将药物部分直接输送到目标身体区域，减少了传统药物输送的毒性作用，从而减少了治疗效果所需的药物量，并提供了更多的优势。目前，这些纳米材料已被广泛应用于癌症治疗、成像对比剂、生物标志物检测等多个领域。本综述通过对药物合成、类型、靶点和纳米医学在提高治疗效率方面的应用进行全面考察，提供了靶向纳米药物输送系统领域的最新进展。
