术前糖尿病对无功能性胰腺神经内分泌肿瘤患者的预后价值。

Prognostic value of preoperative diabetes mellitus in patients with non-functional pancreatic neuroendocrine neoplasms.

机构信息

Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Department of Radiology, The First People's Hospital of Chengdu, Chengdu, Sichuan Province, China.

出版信息

Am J Surg. 2022 Oct;224(4):1162-1167. doi: 10.1016/j.amjsurg.2022.05.026. Epub 2022 May 25.

DOI:10.1016/j.amjsurg.2022.05.026

PMID:35637016

Abstract

BACKGROUND

The main aim of this study was to investigate the prevalence and prognostic value of preoperative diabetes mellitus (DM) in patients with non-functional pancreatic neuroendocrine neoplasms (NF-PNENs).

METHODS

Data were retrospectively collected from 190 patients with NF-PNENs from January 2009 to December 2019 in a single center.

RESULTS

The prevalence of longstanding DM, new-onset DM and impaired fasting glucose (IFG) was 11.6% (22/190), 8.4% (16/190), and 25.8% (49/190), respectively. Regression analysis showed that tumor size, tumor grade and lymph node metastasis were risk factors for new-onset DM and IFG. Multivariate survival analysis demonstrated preoperative new-onset DM (hazard ratio [HR], 4.33; P = 0.009) and IFG (HR, 4.53; P = 0.027) as independent predictors of poor recurrence-free survival (RFS) in patients with NF-PNENs.

CONCLUSION

Preoperative new-onset DM and IFG are associated with aggressive tumor behavior and poor RFS in patients with NF-PNENs.

摘要

背景

本研究的主要目的是探讨术前糖尿病（DM）在无功能性胰腺神经内分泌肿瘤（NF-PNENs）患者中的患病率及其预后价值。

方法

本研究回顾性分析了 2009 年 1 月至 2019 年 12 月在单一中心接受治疗的 190 例 NF-PNENs 患者的数据。

结果

长期 DM、新发 DM 和空腹血糖受损（IFG）的患病率分别为 11.6%（22/190）、8.4%（16/190）和 25.8%（49/190）。回归分析显示，肿瘤大小、肿瘤分级和淋巴结转移是新发 DM 和 IFG 的危险因素。多因素生存分析表明，术前新发 DM（风险比 [HR]，4.33；P=0.009）和 IFG（HR，4.53；P=0.027）是 NF-PNENs 患者无复发生存（RFS）不良的独立预测因素。