Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Department of Radiology, The First People's Hospital of Chengdu, Chengdu, Sichuan Province, China.
Am J Surg. 2022 Oct;224(4):1162-1167. doi: 10.1016/j.amjsurg.2022.05.026. Epub 2022 May 25.
The main aim of this study was to investigate the prevalence and prognostic value of preoperative diabetes mellitus (DM) in patients with non-functional pancreatic neuroendocrine neoplasms (NF-PNENs).
Data were retrospectively collected from 190 patients with NF-PNENs from January 2009 to December 2019 in a single center.
The prevalence of longstanding DM, new-onset DM and impaired fasting glucose (IFG) was 11.6% (22/190), 8.4% (16/190), and 25.8% (49/190), respectively. Regression analysis showed that tumor size, tumor grade and lymph node metastasis were risk factors for new-onset DM and IFG. Multivariate survival analysis demonstrated preoperative new-onset DM (hazard ratio [HR], 4.33; P = 0.009) and IFG (HR, 4.53; P = 0.027) as independent predictors of poor recurrence-free survival (RFS) in patients with NF-PNENs.
Preoperative new-onset DM and IFG are associated with aggressive tumor behavior and poor RFS in patients with NF-PNENs.
本研究的主要目的是探讨术前糖尿病（DM）在无功能性胰腺神经内分泌肿瘤（NF-PNENs）患者中的患病率及其预后价值。
本研究回顾性分析了 2009 年 1 月至 2019 年 12 月在单一中心接受治疗的 190 例 NF-PNENs 患者的数据。
长期 DM、新发 DM 和空腹血糖受损（IFG）的患病率分别为 11.6%（22/190）、8.4%（16/190）和 25.8%（49/190）。回归分析显示，肿瘤大小、肿瘤分级和淋巴结转移是新发 DM 和 IFG 的危险因素。多因素生存分析表明，术前新发 DM（风险比 [HR]，4.33；P=0.009）和 IFG（HR，4.53；P=0.027）是 NF-PNENs 患者无复发生存（RFS）不良的独立预测因素。
术前新发 DM 和 IFG 与 NF-PNENs 患者侵袭性肿瘤行为和不良 RFS 相关。
