从多倍体到多倍体逆转：其在正常和疾病状态中的作用。

From polyploidy to polyploidy reversal: its role in normal and disease states.

机构信息

Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.

Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.

出版信息

Trends Genet. 2022 Oct;38(10):991-995. doi: 10.1016/j.tig.2022.05.007. Epub 2022 May 28.

DOI:10.1016/j.tig.2022.05.007

PMID:35637074

Abstract

Polyploidization and polyploidy reversal (depolyploidization) are crucial pathways to conversely alter genomic contents in organisms. Understanding the mechanisms switching between polyploidization and polyploidy reversal should broaden our knowledge of the generation of pathological polyploidy and pave a new path to prevent related diseases.

摘要

多倍化和多倍体逆转（去多倍化）是在生物中反向改变基因组内容的关键途径。理解在多倍化和多倍体逆转之间切换的机制应该拓宽我们对病理性多倍体产生的认识，并为预防相关疾病开辟新的途径。