PD-L1 阳性宫颈癌的皮肤转移
Cutaneous metastasis of PD-L1 positive cervical carcinoma.
作者信息
Liu Chrissy, Zhou Nancy, Levitan Daniel, Coca Guzman Juan, Fehniger Julia
机构信息
State University of New York (SUNY) Downstate Health Sciences University, Department of Obstetrics and Gynecology, Brooklyn, NY, United States.
State University of New York (SUNY) Downstate Health Sciences University, Division of Gynecologic Oncology, Brooklyn, NY, United States.
出版信息
Gynecol Oncol Rep. 2022 May 18;41:101003. doi: 10.1016/j.gore.2022.101003. eCollection 2022 Jun.
Abstract
•Cutaneous metastases in cervical cancer are rare and associated with a poor prognosis.•Treatment is typically palliative, utilizing chemotherapy and radiation.•We report a case of PD-L1 positive cervical cancer with cutaneous metastases that developed after initial recurrence.•For patients on checkpoint inhibitor therapy who develop skin toxicity, it is important to rule out cutaneous metastases.
摘要
•宫颈癌的皮肤转移罕见，且预后不良。
•治疗通常是姑息性的，采用化疗和放疗。
•我们报告一例初始复发后发生皮肤转移的PD-L1阳性宫颈癌病例。
•对于接受检查点抑制剂治疗且出现皮肤毒性的患者，排除皮肤转移很重要。
相似文献
1
Cutaneous metastasis of PD-L1 positive cervical carcinoma.
Gynecol Oncol Rep. 2022 May 18;41:101003. doi: 10.1016/j.gore.2022.101003. eCollection 2022 Jun.
2
PD-L1, PARP1, and MMRs as potential therapeutic biomarkers for neuroendocrine cervical cancer.
Cancer Med. 2021 Jul;10(14):4743-4751. doi: 10.1002/cam4.4034. Epub 2021 Jun 2.
3
Cutaneous metastatic disease in cervical cancer: a case report.
J Obstet Gynaecol Can. 2010 May;32(5):467-472. doi: 10.1016/S1701-2163(16)34501-7.
4
Cutaneous Metastasis From Tonsillar Squamous Cell Carcinoma: Report and Review of the Literature.
Cureus. 2017 Mar 28;9(3):e1122. doi: 10.7759/cureus.1122.
5
Programmed cell death ligand-1 and cytotoxic T cell infiltrates in metastatic cutaneous squamous cell carcinoma of the head and neck.
Head Neck. 2020 Nov;42(11):3226-3234. doi: 10.1002/hed.26370. Epub 2020 Aug 1.
6
A case report of carcinoma of uterine cervix throwing heterochronous metastasis to the skin, spleen, and pancreas: the role of multimodality treatment approach.
J Egypt Natl Canc Inst. 2019 Dec 16;31(1):8. doi: 10.1186/s43046-019-0009-9.
7
PD-L1 Expression is Increased in Metastasizing Squamous Cell Carcinomas and Their Metastases.
Am J Dermatopathol. 2018 Sep;40(9):647-654. doi: 10.1097/DAD.0000000000001164.
8
Metastatic laryngeal carcinoma mimicking eruptive keratoacanthomas: report of keratoacanthoma-like cutaneous metastases in a radiation port.
Dermatol Online J. 2014 Sep 16;20(9):13030/qt3s43b81f.
9
Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma.
Int J Oral Maxillofac Surg. 2018 Jul;47(7):836-845. doi: 10.1016/j.ijom.2018.01.004. Epub 2018 Feb 1.
10
Association between PD-L1 expression and initial brain metastasis in patients with non-small cell lung cancer and its clinical implications.
Thorac Cancer. 2021 Aug;12(15):2143-2150. doi: 10.1111/1759-7714.14006. Epub 2021 Jun 13.
引用本文的文献
1
Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosis.
Front Immunol. 2025 Jan 20;15:1528957. doi: 10.3389/fimmu.2024.1528957. eCollection 2024.
2
Cutaneous metastasis from cervical cancer to the scalp and trunk: a case report and review of the literature.
J Med Case Rep. 2023 Oct 19;17(1):435. doi: 10.1186/s13256-023-04171-x.
本文引用的文献
1
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update.
J Clin Oncol. 2021 Dec 20;39(36):4073-4126. doi: 10.1200/JCO.21.01440. Epub 2021 Nov 1.
2
Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer.
N Engl J Med. 2021 Nov 11;385(20):1856-1867. doi: 10.1056/NEJMoa2112435. Epub 2021 Sep 18.
3
Keynote-158 study, FDA granted accelerated approval of pembrolizumab for the treatment of patients with advanced PD-L1-positive cervical cancer.
Ann Transl Med. 2020 Dec;8(23):1611. doi: 10.21037/atm-20-2656.
4
PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential.
Front Immunol. 2020 Dec 17;11:596825. doi: 10.3389/fimmu.2020.596825. eCollection 2020.
5
High-Risk HPV Oncoproteins and PD-1/PD-L1 Interplay in Human Cervical Cancer: Recent Evidence and Future Directions.
Front Oncol. 2020 Jun 30;10:914. doi: 10.3389/fonc.2020.00914. eCollection 2020.
6
Pembrolizumab Monotherapy for Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma: A Single-Arm Phase II Trial (KEYNOTE-629).
J Clin Oncol. 2020 Sep 1;38(25):2916-2925. doi: 10.1200/JCO.19.03054. Epub 2020 Jul 16.
7
Immune checkpoint inhibitor-related dermatologic adverse events.
J Am Acad Dermatol. 2020 Nov;83(5):1255-1268. doi: 10.1016/j.jaad.2020.03.132. Epub 2020 May 23.
8
Skin metastasis from squamous cell carcinoma of the cervix to the lower extremities: Case report and review of the literature.
J Family Med Prim Care. 2019 Oct 31;8(10):3443-3446. doi: 10.4103/jfmpc.jfmpc_541_19. eCollection 2019 Oct.
9
Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study.
J Clin Oncol. 2019 Jun 10;37(17):1470-1478. doi: 10.1200/JCO.18.01265. Epub 2019 Apr 3.
10
Cutaneous metastasis in cancer of the uterine cervix: A case report and review of the literature.
J Turk Ger Gynecol Assoc. 2013 Jul 10;14(3):174-7. doi: 10.5152/jtgga.2013.62444. eCollection 2013.
Zotero 插件