St Laurent Jessica D, Silberman Jason N, Worley Michael J
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Dana-Farber Cancer Institute, Boston, MA, USA.
Gynecol Oncol Rep. 2022 May 19;41:100991. doi: 10.1016/j.gore.2022.100991. eCollection 2022 Jun.
In recurrent ovarian cancer patients the addition of surgical cytoreduction is associated with prolonged overall survival compared to chemotherapy treatment alone when complete cytoreduction is achieved (Harter et al., 2021, Shi et al., 2021, Coleman et al., 2019). In the appropriate surgical candidates, a minimally invasive approach may be used to achieve complete cytoreduction of isolated lesions with proper exposure and surgical planning. This video demonstrates safe robotic entry into the lesser sac and resection of recurrent high-grade serous ovarian carcinoma near the pancreatic neck. The patient is a 78-year-old BRCA negative female with a history of a stage IIIC high-grade serous carcinoma. She previously underwent cytoreductive surgery and adjuvant chemotherapy in 2018 and presented 24 months later with a normal CA 125 and CT findings of an isolated lesion near the porta hepatis. An MRI was obtained preoperatively to further characterize the location of the lesion demonstrating a 2.2 × 1.6 cm hypoechoic mass adjacent to the pancreatic neck. Given the patient's prolonged disease-free interval, fitness for surgery and single site of disease, she met strict inclusion criteria for recent studies demonstrating clinical benefit with secondary cytoreduction (Harter et al., 2021, Shi et al., 2021). She was taken for a robotic secondary cytoreduction. At subsequent follow up 7 months later, our patient was still disease free and continues surveillance. In this video, we demonstrate the careful dissection of this isolated lesion from the omental bursa. We review important pre-procedural and anatomic considerations for robotic surgery in the lesser sac.
在复发性卵巢癌患者中,与单纯化疗相比,若能实现完全肿瘤细胞减灭,加做手术细胞减灭术可延长总生存期(Harter等人,2021年;Shi等人,2021年;Coleman等人,2019年)。对于合适的手术候选患者,可采用微创方法,通过适当的暴露和手术规划来实现对孤立病灶的完全肿瘤细胞减灭。本视频展示了机器人安全进入网膜囊并切除胰颈附近复发性高级别浆液性卵巢癌的过程。患者为一名78岁的BRCA阴性女性,有IIIC期高级别浆液性癌病史。她曾在2018年接受过肿瘤细胞减灭术和辅助化疗,24个月后CA 125正常,CT检查发现肝门附近有一个孤立病灶。术前进行了MRI检查,以进一步明确病灶位置,显示胰颈旁有一个2.2×1.6厘米的低回声肿块。鉴于患者疾病缓解期较长、适合手术且为单病灶,她符合近期研究中显示二次肿瘤细胞减灭有临床获益的严格纳入标准(Harter等人,2021年;Shi等人,2021年)。她接受了机器人辅助二次肿瘤细胞减灭术。在随后7个月的随访中,我们的患者仍无疾病进展,并继续接受监测。在本视频中,我们展示了从网膜囊仔细分离这个孤立病灶的过程。我们回顾了在网膜囊进行机器人手术的重要术前和解剖学注意事项。