氟取代的双环[1.1.1]戊烷的实用且可扩展的方法。
A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes.
机构信息
Enamine Ltd., Chervonotkatska 60, 02094, Kyiv, Ukraine.
出版信息
Angew Chem Int Ed Engl. 2022 Jul 18;61(29):e202205103. doi: 10.1002/anie.202205103. Epub 2022 Jun 14.
Abstract
After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.
摘要
经过 20 多年的试验，一种实用的可扩展的氟取代双环[1.1.1]戊烷（F-BCPs）方法已经开发出来。研究了 F-BCPs 的物理化学性质，并将其核心部分取代抗炎药物氟比洛芬中的氟苯基环，融入到其结构中。
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