Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Division of Pharmacy, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Paediatr Child Health. 2022 Sep;58(9):1566-1570. doi: 10.1111/jpc.16034. Epub 2022 May 31.
This study aimed to compare the efficacy of 3% versus 30% NaCl solution in treating umbilical granuloma (UG) and to evaluate parental satisfaction.
A randomised, double-blinded, comparative study in neonates with UG was conducted. Stratified, block-of-four randomisation was used to allocate neonates into two groups, treated with 3% or 30% pharmaceutical-grade NaCl solution, three times daily. The time to resolution was determined by daily photographs of UG and weekly hospital visits. If there was no response after 2 weeks, silver nitrate was used. Parental satisfaction was measured on a rating scale of 1-5.
One hundred neonates were enrolled, 48 in the 3% NaCl group and 52 in the 30% NaCl group. Baseline demographic data were not different between the groups. There was no significant difference in the resolution rate (93.8% vs 98.1%) or the median (interquartile range) time to resolution (7 (5-13) vs 7 (4-11) days) between the 3% and 30% NaCl groups, respectively. No skin burn or cellulitis was detected. About 95% of parents scored >4 for satisfaction.
Hypertonic NaCl solution is highly effective in treating UG without side effects. Hypertonic NaCl solution should be considered as an alternative treatment for UG.
本研究旨在比较 3%与 30%氯化钠溶液治疗脐肉芽肿（UG）的疗效，并评估家长满意度。
对患有 UG 的新生儿进行随机、双盲、对照研究。采用分层、四分组随机化将新生儿分为两组，分别用 3%或 30%医药级氯化钠溶液，每日三次治疗。通过每日 UG 照片和每周医院就诊来确定 UG 消退时间。如果 2 周后无反应，则使用硝酸银。家长满意度采用 1-5 分的评分量表进行测量。
共纳入 100 例新生儿，3%氯化钠组 48 例，30%氯化钠组 52 例。两组间基线人口统计学数据无差异。3%氯化钠组和 30%氯化钠组的消退率（93.8% vs 98.1%）或中位（四分位距）消退时间（7（5-13） vs 7（4-11）天）均无显著差异。未发现皮肤烧伤或蜂窝织炎。约 95%的家长对满意度评分>4。
高渗氯化钠溶液治疗 UG 有效，无副作用。高渗氯化钠溶液应作为 UG 的替代治疗方法。
