Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
BMJ Open. 2023 Oct 24;13(10):e076931. doi: 10.1136/bmjopen-2023-076931.
The most frequent umbilical abnormality in infancy period is umbilical granuloma. Although umbilical granuloma treatment with silver nitrate is practised worldwide, silver nitrate cauterisation is high in cost and if silver nitrate comes into contact with healthy tissues, it might cause injury. This systematic review aims to look for evidence concerning the safety and efficacy of all interventions for treating umbilical granuloma in neonates.
Individual and cluster randomised controlled trials will be included in our study. The direct comparisons between two of any interventions for treating umbilical granuloma, including silver nitrate cauterisation, dry care, common salt, alcoholic wipes, topical doxycycline, topical steroid ointment, ligatures, cryosurgery, electrocautery, surgical excision and no intervention will be investigated. Primary outcomes will be the healing rate after 2 weeks of treatment and the incidence of cord-related adverse events. We will search CENTRAL, Embase and MEDLINE.
Ethical approval is not applicable in this study since we will retrieve and analyse data from previous published studies. The results of this systematic review are expected to be published in a scientific journal and presented at medical conferences.
CRD42022369915.
婴儿期最常见的脐部异常是脐肉芽肿。尽管全世界都在使用硝酸银治疗脐肉芽肿，但硝酸银烧灼的费用很高，如果硝酸银接触到健康组织，可能会造成损伤。本系统评价旨在寻找有关治疗新生儿脐肉芽肿的所有干预措施的安全性和有效性的证据。
本研究将纳入个体和群组随机对照试验。将对两种或多种干预措施治疗脐肉芽肿的直接比较进行研究，包括硝酸银烧灼、干护理、食盐、酒精湿巾、局部多西环素、局部皮质类固醇软膏、结扎、冷冻疗法、电灼、手术切除和不干预。主要结局将是治疗 2 周后的愈合率和脐带相关不良事件的发生率。我们将检索 CENTRAL、Embase 和 MEDLINE。
由于我们将从以前发表的研究中检索和分析数据，因此本研究不适用伦理批准。预计该系统评价的结果将发表在科学期刊上，并在医学会议上展示。
PROSPERO 注册号：CRD42022369915。
