用于 3D 打印生物相容性和坚韧血管网络的聚氨酯-明胶甲基丙烯酰混合墨水。
Polyurethane-gelatin methacryloyl hybrid ink for 3D printing of biocompatible and tough vascular networks.
机构信息
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China.
出版信息
Chem Commun (Camb). 2022 Jun 16;58(49):6894-6897. doi: 10.1039/d2cc02176e.
A polyurethane-gelatin methacryloyl (PU-GelMA) hybrid ink was developed as a photo-crosslinkable elastic hydrogel. With the additional acrylic monomer, the ink can be tuned to accommodate elasticity and printability. Attributed to the shear-thinning properties of GelMA, PU-GelMA was preferable for extrusion printing. 3D-constructs were printed by direct extrusion or by using a sacrificial scaffold to resemble the vascular networks. The proliferation of endothelial cells on the PU-GelMA hydrogel indicated decent biocompatibility and potential utilization in artificial vessels.
开发了一种聚氨酯-明胶甲基丙烯酰（PU-GelMA）混合墨水，作为一种光交联弹性水凝胶。通过添加丙烯酸单体，可以调整墨水的弹性和可打印性。由于 GelMA 的剪切稀化特性，PU-GelMA 更适合挤出打印。通过直接挤出或使用牺牲支架来模拟血管网络，可以打印 3D 结构。内皮细胞在 PU-GelMA 水凝胶上的增殖表明其具有良好的生物相容性，有望用于人工血管。
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