Cai Yu, Wang Zhengchao, Liao Bokai, Sun Zhenxing, Zhu Pengfei
Department of Rehabilitation, Wuhan Fourth Hospital, Wuhan, China.
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78(1):51-59. doi: 10.1093/gerona/glac118.
Osteoarthritis (OA) is a common and challenging joint disease that mainly affects the diarthrodial joints. Traditionally, except for surgery for severe cases, treatments for OA mainly focus on relieving pain and improving joint function. However, these treatments are not effective for cartilage repair and induce only symptomatic relief. Platelet-derived growth factor (PDGF)-BB, a member of the PDGF cytokine family, has been proved to have effects on protecting the chondrocytes via multiple mechanisms. In this study, we further focused on the effects of PDGF-BB on OA and found that PDGF-BB could attenuate OA development by inhibiting inflammation and enhancing cell proliferation via JAK2/STAT3, PI3K/AKT, and p38 signaling pathways and PKA-mediated regulation of SOX-9/RunX-2. This article demonstrates the feasibility of PDGF-BB application as a treatment for OA. This is the first article that reports that PDGF-BB attenuates OA development via PKA-mediated regulation of SOX-9 and RunX-2.
骨关节炎（OA）是一种常见且具有挑战性的关节疾病，主要影响滑膜关节。传统上，除了对严重病例进行手术外，OA的治疗主要集中在缓解疼痛和改善关节功能。然而，这些治疗方法对软骨修复无效，仅能缓解症状。血小板衍生生长因子（PDGF）-BB是PDGF细胞因子家族的成员之一，已被证明可通过多种机制对软骨细胞起到保护作用。在本研究中，我们进一步聚焦于PDGF-BB对OA的影响，发现PDGF-BB可通过JAK2/STAT3、PI3K/AKT和p38信号通路以及PKA介导的SOX-9/RunX-2调节来抑制炎症并增强细胞增殖，从而减轻OA的发展。本文证明了PDGF-BB作为OA治疗方法应用的可行性。这是第一篇报道PDGF-BB通过PKA介导的SOX-9和RunX-2调节减轻OA发展的文章。
