iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal; LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
Food Chem. 2022 Oct 15;391:133261. doi: 10.1016/j.foodchem.2022.133261. Epub 2022 May 20.
Discovery of new selective anticancer, anti-inflammatory, and anti-microbial agents is a crucial and necessary step to ensure a pipeline for innovative products to improve disease management. Several new bioactive agents derived from plants have been investigated and an example is the steroidal glycoalkaloid (SGA) class of natural products found in plants, investigated for their health-beneficial biological activities. Among them, α-tomatine is a SGA derived from the plant parts of unripe green tomatoes. In this review we aimed at searching for two different perspectives to study α-tomatine from green tomatoes, namely from its dual action point of view: as an anti-nutrient and as a health promoter. The aspects associated to its synthesis and degradation were considered. Finally, the current strategies for its extraction from natural sources and the methodologies commonly used for its identification and quantification were discussed.
发现新的选择性抗癌、抗炎和抗微生物药物是确保创新产品管道以改善疾病管理的关键和必要步骤。已经研究了几种源自植物的新型生物活性物质，甾体糖苷生物碱 (SGA) 类天然产物就是一个例子，它们因其有益健康的生物活性而受到关注。其中，α-茄碱是一种源自未成熟绿番茄植物部分的 SGA。在本综述中，我们旨在从两个不同的角度研究绿番茄中的 α-茄碱，即从其双重作用的角度：作为抗营养物质和促进健康的物质。考虑了与其合成和降解相关的方面。最后，讨论了从天然来源提取它的当前策略以及用于鉴定和定量它的常用方法。
