Ghosh Sumit, Das Sanjib Kumar, Sinha Krishnendu, Ghosh Biswatosh, Sen Koushik, Ghosh Nabanita, Sil Parames C
Department of Zoology, Ramakrishna Mission Vidyamandira, Belur Math, Howrah, 711202, India.
Division of Molecular Medicine, Bose Institute, Kolkata, 700054, India.
Arch Toxicol. 2024 Aug;98(8):2353-2391. doi: 10.1007/s00204-024-03786-3. Epub 2024 May 25.
The exploration of natural products as potential agents for cancer treatment has garnered significant attention in recent years. In this comprehensive review, we delve into the diverse array of natural compounds, including alkaloids, carbohydrates, flavonoids, lignans, polyketides, saponins, tannins, and terpenoids, highlighting their emerging roles in cancer therapy. These compounds, derived from various botanical sources, exhibit a wide range of mechanisms of action, targeting critical pathways involved in cancer progression such as cell proliferation, apoptosis, angiogenesis, and metastasis. Through a meticulous examination of preclinical and clinical studies, we provide insights into the therapeutic potential of these natural products across different cancer types. Furthermore, we discuss the advantages and challenges associated with their use in cancer treatment, emphasizing the need for further research to optimize their efficacy, pharmacokinetics, and delivery methods. Overall, this review underscores the importance of natural products in advancing cancer therapeutics and paves the way for future investigations into their clinical applications.
近年来，探索天然产物作为癌症治疗的潜在药物受到了广泛关注。在这篇全面综述中，我们深入研究了各种天然化合物，包括生物碱、碳水化合物、黄酮类化合物、木脂素、聚酮化合物、皂苷、单宁和萜类化合物，突出它们在癌症治疗中日益重要的作用。这些来自不同植物来源的化合物表现出广泛的作用机制，针对癌症进展中涉及的关键途径，如细胞增殖、凋亡、血管生成和转移。通过对临床前和临床研究的细致审查，我们深入了解了这些天然产物对不同癌症类型的治疗潜力。此外，我们讨论了在癌症治疗中使用它们的优势和挑战，强调需要进一步研究以优化其疗效、药代动力学和给药方法。总体而言，本综述强调了天然产物在推进癌症治疗方面的重要性，并为其临床应用的未来研究铺平了道路。
