Shiri Aghbash Parisa, Shirvaliloo Milad, Khalo Abass Kasho Ammar, Alinezhad Farbod, Nauwynck Hans, Bannazadeh Baghi Hossein
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Int Immunopharmacol. 2022 Jul;108:108896. doi: 10.1016/j.intimp.2022.108896. Epub 2022 May 28.
Viruses may transform infected cells into benign or malignant tumors, promoting cell growth and survival via various intracellular pathways. Some oncogenic DNA viruses, such as human papillomaviruses, can lead to squamous intraepithelial lesions and cervical cancer. Furthermore, the early HPV virus'soncoproteins have been attributed to cancer initiation and development and tumor-enhancing action. In addition to viral oncoproteins, antigen-presenting cells (APC) and the number of clusters of differentiation (CD) markers expressed on their surface play an essential role in disease progression or tumorigenesis inhibition. This article discussed the function of CD markers in the interaction between APCs and cancer cells, immune cells' function in the infection process, and finally infected cells' malignancy. We investigated targeting these markers as a novel insight to create a new therapeutic or diagnosis strategy to prevent cervical cancer progression.
病毒可将受感染细胞转化为良性或恶性肿瘤，通过各种细胞内途径促进细胞生长和存活。一些致癌DNA病毒，如人乳头瘤病毒，可导致鳞状上皮内病变和宫颈癌。此外，早期人乳头瘤病毒的癌蛋白与癌症的发生、发展及肿瘤增强作用有关。除病毒癌蛋白外，抗原呈递细胞（APC）及其表面表达的分化簇（CD）标志物数量在疾病进展或肿瘤发生抑制中起重要作用。本文讨论了CD标志物在APC与癌细胞相互作用中的功能、免疫细胞在感染过程中的作用，以及最终受感染细胞的恶性程度。我们研究了将这些标志物作为一种新的见解，以创建一种新的治疗或诊断策略来预防宫颈癌进展。
