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基于 PSP-Net+VGG16 深度学习网络的前列腺肿瘤医学影像诊断。

Medical image diagnosis of prostate tumor based on PSP-Net+VGG16 deep learning network.

机构信息

Department of Urology, The First People's Hospital of Fuyang, Hangzhou 311400, China.

Department of Radiation Oncology, The First People's Hospital of Fuyang, Hangzhou 311400, China.

出版信息

Comput Methods Programs Biomed. 2022 Jun;221:106770. doi: 10.1016/j.cmpb.2022.106770. Epub 2022 Mar 23.

Abstract

BACKGROUND AND OBJECTIVE

Prostate cancer is the most common cancer of the male reproductive system. With the development of medical imaging technology, magnetic resonance images (MRI) have been used in the diagnosis and treatment of prostate cancer because of its clarity and non-invasiveness. Prostate MRI segmentation and diagnosis experience problems such as low tissue boundary contrast. The traditional segmentation method of manually drawing the contour boundary of the tissue cannot meet the clinical real-time requirements. How to quickly and accurately segment the prostate tumor has become an important research topic.

METHODS

This paper proposes a prostate tumor diagnosis based on the deep learning network PSP-Net+VGG16. The deep convolutional neural network segmentation method based on the PSP-Net constructs a atrous convolution residual structure model extraction network. First, the three-dimensional prostate MRI is converted to two-dimensional image slices, and then the slice input of the two-dimensional image is trained based on the PSP-Net neural network; and the VGG16 network is used to analyze the region of interest and classify prostate cancer and normal prostate.

RESULTS

According to the experimental results, the segmentation method based on the deep learning network PSP-Net is used to identify the data set samples. The segmentation accuracy is close to the Dice similarity coefficient and Hausdorff distance, and even exceeds the traditional prostate image segmentation method. The Dice index reached 91.3%, and the technique is superior in speed of processing. The predicted tumor markers are very close to the actual markers manually by clinicians; the classification accuracy and recognition rates of prostate MRI based on VGG16 are as high as 87.95% and 87.33%, and the accuracy rate and recall rate of the network model are relatively balanced. The area under curve index is also higher than other models, with good generalization ability.

CONCLUSION

Experiments show that prostate cancer diagnosis based on the deep learning network PSP-Net+VGG16 is superior in accuracy and processing time compared to other algorithms, and can be well applied to clinical prostate tumor diagnosis.

摘要

背景与目的

前列腺癌是男性生殖系统最常见的癌症。随着医学影像学技术的发展,磁共振成像(MRI)因其清晰度和非侵入性而被用于前列腺癌的诊断和治疗。前列腺 MRI 分割和诊断存在组织边界对比度低等问题。传统的手动绘制组织轮廓边界的分割方法不能满足临床实时性的要求。如何快速准确地分割前列腺肿瘤已成为一个重要的研究课题。

方法

本文提出了一种基于深度学习网络 PSP-Net+VGG16 的前列腺肿瘤诊断方法。基于 PSP-Net 的深度卷积神经网络分割方法构建了一个空洞卷积残差结构模型提取网络。首先,将三维前列腺 MRI 转换为二维图像切片,然后基于 PSP-Net 神经网络对二维图像的切片输入进行训练;并使用 VGG16 网络分析感兴趣区域并对前列腺癌和正常前列腺进行分类。

结果

根据实验结果,使用基于深度学习网络 PSP-Net 的分割方法对数据集样本进行识别。分割精度接近 Dice 相似系数和 Hausdorff 距离,甚至超过传统的前列腺图像分割方法。Dice 指数达到 91.3%,处理速度快。预测的肿瘤标志物与临床医生手动标记的标志物非常接近;基于 VGG16 的前列腺 MRI 的分类准确率和识别率高达 87.95%和 87.33%,网络模型的准确率和召回率相对平衡。曲线下面积指数也高于其他模型,具有良好的泛化能力。

结论

实验表明,基于深度学习网络 PSP-Net+VGG16 的前列腺癌诊断在准确性和处理时间方面优于其他算法,可以很好地应用于临床前列腺肿瘤诊断。

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