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ROR1 targeted immunoliposomal delivery of OSU-2S shows selective cytotoxicity in t(1;19)(q23;p13) translocated B-cell acute lymphoblastic leukemia.

作者信息

Goswami Swagata, Chiang Chi-Ling, Zapolnik Kevan, Nunes Jessica, Ventura Ann, Mo Xiaokui, Xie Zhiliang, Lee L James, Baskar Sivasubramanian, Rader Christoph, Byrd John C, Phelps Mitch, Bhatnagar Bhavana, Muthusamy Natarajan

机构信息

Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH, USA.

Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

出版信息

Leuk Res. 2022 Jul;118:106872. doi: 10.1016/j.leukres.2022.106872. Epub 2022 May 24.

DOI:10.1016/j.leukres.2022.106872
PMID:35640397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10029232/
Abstract
摘要

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PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia.蛋白磷酸酶 2A 通过 c-Myc/p21 轴是人类和小鼠急性髓系白血病中具有治疗潜力的细胞命运决定的驱动因素。
Blood. 2022 Mar 3;139(9):1340-1358. doi: 10.1182/blood.2020010344.
2
The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia.ROR1 抗体偶联药物 huXBR1-402-G5-PNU 能够有效靶向 ROR1+白血病。
Blood Adv. 2021 Aug 24;5(16):3152-3162. doi: 10.1182/bloodadvances.2020003276.
3
Clinical features and prognostic impact of TCF3-PBX1 in childhood acute lymphoblastic leukemia: A single-center retrospective study of 837 patients from China.
中国单中心 837 例儿童急性淋巴细胞白血病患者中 TCF3-PBX1 的临床特征及预后影响：一项回顾性研究。
Curr Probl Cancer. 2021 Dec;45(6):100758. doi: 10.1016/j.currproblcancer.2021.100758. Epub 2021 May 16.
4
Pharmacokinetics and Tolerability of the Novel Non-immunosuppressive Fingolimod Derivative, OSU-2S, in Dogs and Comparisons with Data in Mice and Rats.新型非免疫抑制性芬戈莫德衍生物 OSU-2S 在犬中的药代动力学和耐受性研究及其与小鼠和大鼠数据的比较。
AAPS J. 2020 Jul 16;22(4):92. doi: 10.1208/s12248-020-00474-9.
5
ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model.ROR1 靶向递送 miR-29b 在体内诱导 CLL 小鼠模型中的细胞周期停滞和治疗获益。
Blood. 2019 Aug 1;134(5):432-444. doi: 10.1182/blood.2018882290. Epub 2019 May 31.
6
Clinical translation of immunoliposomes for cancer therapy: recent perspectives.免疫脂质体用于癌症治疗的临床转化：最新观点。
Expert Opin Drug Deliv. 2018 Sep;15(9):893-903. doi: 10.1080/17425247.2018.1517747. Epub 2018 Sep 12.
7
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Cell Stem Cell. 2018 Jun 1;22(6):951-959.e3. doi: 10.1016/j.stem.2018.05.018.
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Leukemia. 2015 Feb;29(2):346-55. doi: 10.1038/leu.2014.199. Epub 2014 Jun 20.
10
Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.ROR1 与前 B 细胞受体的串扰促进 t(1;19) 急性淋巴细胞白血病的存活。
Cancer Cell. 2012 Nov 13;22(5):656-67. doi: 10.1016/j.ccr.2012.08.027.