Bhat B G, Chandrasekhara N
Toxicology. 1987 Apr;44(1):91-8.
Pretreatment of adult male albino rats with piperine did not induce cytochrome P-450 whereas safrole did cause such induction. Piperine and safrole interacted with different forms of cytochrome P-450 as indicated by their in vivo effect on drug metabolising enzymes and mixed function oxidases and electrophoretic patterns. Incubation of piperine or safrole with dithionite- or NADPH-reduced microsomes from untreated rats resulted in a modified type II difference spectrum with an absorption maximum at 427 nm and a trough at 408 nm.
用胡椒碱对成年雄性白化大鼠进行预处理不会诱导细胞色素P - 450，而黄樟素则会引起这种诱导。胡椒碱和黄樟素与细胞色素P - 450的不同形式相互作用，这从它们对药物代谢酶、混合功能氧化酶的体内作用以及电泳图谱中可以看出。将胡椒碱或黄樟素与来自未处理大鼠的连二亚硫酸盐或NADPH还原的微粒体一起孵育，会产生一种修饰的II型差异光谱，其最大吸收峰在427nm，谷值在408nm。
