Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA.
Department of Sociology, University of Chicago, 1126 E 59th St., Chicago, IL 60637, USA.
Conscious Cogn. 2022 Jul;102:103357. doi: 10.1016/j.concog.2022.103357. Epub 2022 May 28.
Altered states of consciousness (ASC) provide an opportunity for researchers to study the neurophysiological basis of changes in phenomenal experience. Δ9-tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis, however whether the effects of THC include ASC features that are shared with other ASC induction mechanisms, such as classical psychedelics, has not been systematically addressed. We used survey (11D-ASC; State Mindfulness), self-report, and natural language processing (NLP) to assess 7.5 and 15 mg oral THC, relative to placebo, in 25 healthy, infrequent cannabis users. THC dose-dependently increased measures of ASC including Insightfulness, and increased ratings of mindfulness and mind-wandering. THC also increased language entropy as previously reported for LSD. Future studies may seek to determine whether reports of increased mindfulness or insight after THC are primarily representative of a psychotomimetic state (i.e., delusional thinking) or conversely, reflect an enhancement of conscious awareness that may be validated empirically.
意识改变状态（ASC）为研究人员提供了一个机会，可用于研究现象体验变化的神经生理基础。Δ9-四氢大麻酚（THC）是大麻的主要精神活性成分，但是，THC 的作用是否包括与其他 ASC 诱导机制（如经典迷幻药）共享的 ASC 特征，尚未得到系统解决。我们使用调查（11D-ASC；状态正念）、自我报告和自然语言处理（NLP）来评估 25 名健康、不常使用大麻的使用者口服 7.5 和 15 毫克 THC 与安慰剂相比的效果。THC 剂量依赖性地增加了 ASC 的测量指标，包括洞察力，并增加了正念和走神的评分。正如之前报道的那样，THC 还增加了语言熵。未来的研究可能会试图确定在 THC 之后报告的正念或洞察力增加主要是精神模拟状态（即妄想思维）的代表，还是相反，反映了可以通过经验验证的意识增强。
