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法洛四联症中使用肺动脉瓣修复:这是否可以避免心室功能障碍?

Repair with a pulmonary neovalve in tetralogy of Fallot: does this avoid ventricular dysfunction?

机构信息

Department of Cardiovascular Surgery, Fundación Cardioinfantil-IC, Rosario University, Bogotá, Colombia.

出版信息

Interact Cardiovasc Thorac Surg. 2022 Jul 9;35(2). doi: 10.1093/icvts/ivac155.

Abstract

OBJECTIVES

Given the anatomical variations of tetralogy of Fallot (TOF), different surgical techniques can be used to achieve correction. Transannular patches (TAPs) are the most commonly used technique; they are associated with right ventricular dysfunction, the incidence of which can be reduced through pulmonary valve preservation.

METHODS

Between January 2010 and July 2019, we performed 274 surgical corrections of tetralogy of Fallot at Fundación Cardioinfantil; 63 patients (23%) underwent repair with a TAP in addition to a pulmonary neovalve (Group I), 66 patients (24.1%) received a TAP without a pulmonary valve (Group II) and 145 patients (52.9%) had a repair with valve preservation (Group III). We analysed patient's characteristics before, during and after surgery at a 30-day follow-up.

RESULTS

We found that patients in Group III were older (P = 0.04). Group II had the lowest level of O2 saturation before surgery (82%, P = 0.001). Cardiopulmonary bypass and aortic cross-clamp times were longer in Group I (P < 0.001). Right ventricular dysfunction was less frequent in Group III (15.9%, P = 0.011). Severe residual pulmonary regurgitation was more common in Group II (21.9%, P = 0.001).

CONCLUSIONS

Preservation of the pulmonary valve is an important factor for immediate postoperative management of tetralogy of Fallot. Patients who were repaired with a TAP with or without a pulmonary neovalve had a higher incidence of right ventricular dysfunction than those with pulmonary valve preservation.

摘要

目的

鉴于法洛四联症(TOF)的解剖变异,可采用不同的手术技术进行矫正。跨瓣环补片(TAP)是最常用的技术;它与右心室功能障碍有关,通过保留肺动脉瓣可以降低其发生率。

方法

2010 年 1 月至 2019 年 7 月,我们在 Fundación Cardioinfantil 进行了 274 例法洛四联症的手术矫正;63 例患者(23%)接受了 TAP 加肺动脉新瓣修复(I 组),66 例患者(24.1%)接受了 TAP 无肺动脉瓣修复(II 组),145 例患者(52.9%)接受了保留瓣膜修复(III 组)。我们分析了患者在术前、术中及术后 30 天随访时的特征。

结果

我们发现 III 组患者年龄较大(P=0.04)。II 组患者术前血氧饱和度最低(82%,P=0.001)。I 组患者体外循环和主动脉阻断时间较长(P<0.001)。III 组患者右心室功能障碍发生率较低(15.9%,P=0.011)。II 组患者严重残留肺动脉瓣反流更为常见(21.9%,P=0.001)。

结论

保留肺动脉瓣是法洛四联症术后即刻处理的一个重要因素。接受 TAP 加或不加肺动脉新瓣修复的患者比接受肺动脉瓣保留修复的患者右心室功能障碍发生率更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a35/9297514/3f31f7ee6450/ivac155f4.jpg

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