CHU Nantes, Nantes Université, Service de Medecine et Biologie de la Reproduction et Gynecologie Medicale, Nantes, France; Nantes Université, CHU Nantes, INSERM, Center for Research in Transplantation ans Translational Immunology, UMR 1064, F-44000 Nantes, France; Université de Nantes, Nantes, France.
CHU Nantes, Nantes Université, Service de Medecine et Biologie de la Reproduction et Gynecologie Medicale, Nantes, France.
J Gynecol Obstet Hum Reprod. 2022 Sep;51(7):102414. doi: 10.1016/j.jogoh.2022.102414. Epub 2022 May 28.
Day 5 fresh blastocyst transfers results in higher clinical pregnancy and live birth rates than day 6 fresh blastocyst transfer. This study aimed to identify the strategy to adopt with slowly developing blastocysts. Should not fully expanded blastocyst on day 5 be transferred on day 5, or when expanded on day 6, or be frozen? 1093 single blastocyst transfer cycles performed between January 2016 and December 2018 were divided in 4 groups: day 5 fresh transfers of full or expanded blastocyst (≥B3), day 5 fresh transfers of slowly developing blastocysts (B1 or B2), day 6 fresh transfers of expanded blastocysts (≥B4), day 6 frozen-thawed single blastocyst transfer cycles. Clinical pregnancy rate and live birth rate were significantly higher with fresh expanded blastocyst transfer on day 5 than in any other group. No statistical difference could be found between the other 3 groups. Slowly developing day 5 blastocysts have poorer implantation potential than expanded day 5 blastocysts but can be fresh transferred on day 5 rather than being cultured until day 6 for transfer or freezing when no expanded blastocyst is available on day 5.
第 5 天新鲜囊胚移植的临床妊娠率和活产率高于第 6 天新鲜囊胚移植。本研究旨在确定缓慢发育囊胚的处理策略。第 5 天尚未完全扩张的囊胚应于第 5 天移植，还是等到第 6 天扩张后移植，或者冷冻？2016 年 1 月至 2018 年 12 月期间进行的 1093 个单囊胚移植周期分为 4 组：第 5 天新鲜移植完全或扩张囊胚（≥B3）、第 5 天新鲜移植缓慢发育囊胚（B1 或 B2）、第 6 天新鲜移植扩张囊胚（≥B4）、第 6 天冷冻-解冻单囊胚移植周期。与其他任何组相比，第 5 天新鲜移植扩张囊胚的临床妊娠率和活产率显著更高。其他 3 组之间没有统计学差异。第 5 天缓慢发育的囊胚着床潜能低于第 5 天扩张的囊胚，但可以在第 5 天新鲜移植，而不是培养至第 6 天移植或冷冻，如果第 5 天没有扩张的囊胚。
