Blood levels and distribution of talampicillin and bacampicillin in NZW rabbits.
作者信息
Yamane N, Konnai T, Imoto T, Sekiguchi T, Tomita S, Ohta Y, Sasaki J
出版信息
Tokai J Exp Clin Med. 1986 May;11(2):91-9.
PMID:3564081
Abstract
Parameters for blood concentrations of the peroral antibiotics talampicil in and bacampicillin, in NZW rabbits were determined using a two compartment model. On the basis of these pharmacokinetic parameters, a three compartment model was prepared for the concentrations of these drugs in the tongue, gingiva, submandibular gland, parotid gland, cervical lymph-node and mandibular bone. Simulation curves based on the parameters of tissue concentrations revealed visual conformity to the measured values.
摘要
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