Carbon C, Chau N P, Contrepois A, Lamotte-Barrillon S
Scand J Infect Dis Suppl. 1978(14):127-34.
An animal model in which antibiotic concentrations can be meausred in intersittial fluid (IF) withdrawn from subcutaneous tissue cages has been used. Although the physiological significance of IF is not well established, this model allowed the comparison of 1) two pharmacological forms of the same drug (bacampicillin and ampicillin were compared after a single oral dose; and 2) drugs of the same group in a single i.m. injection study and in a cumulative effect study. These data provide new criteria for clinical choice of antibiotics. A rapid penetration into IF can be explained by a low degree of serum protein binding, but a highly bound drug is not restricted to the intravascular space. In this animal model we have also shown that an 0.25 h i.v. infusion of cephalothin induced higher IF levels than an i.v. bolus injection and an 1 h i.v. infusion. Using a single i.v. bolus injection of various cephalosporins, we have shown that a two open compartment model cannot explain both serum and IF data. Sustained late IF levels suggested the hypothesis of a deep compartment.
已使用一种动物模型，在该模型中可以测量从皮下组织笼中抽出的间质液（IF）中的抗生素浓度。尽管IF的生理意义尚未完全明确，但该模型能够比较：1）同一药物的两种药理学形式（单次口服剂量后比较巴卡西林和氨苄西林）；以及2）在单次肌肉注射研究和累积效应研究中同一组药物。这些数据为抗生素的临床选择提供了新的标准。快速渗透到IF中可以用血清蛋白结合程度低来解释，但高度结合的药物并不局限于血管内空间。在这个动物模型中，我们还表明，静脉输注头孢噻吩0.25小时所诱导的IF水平高于静脉推注和静脉输注1小时。通过单次静脉推注各种头孢菌素，我们已经表明，二室开放模型无法解释血清和IF数据。持续的晚期IF水平提示了深部隔室的假说。
