Otolaryngology, NHS Highland, Inverness, UK
Otolaryngology, NHS Highland, Inverness, UK.
BMJ Case Rep. 2022 May 31;15(5):e248879. doi: 10.1136/bcr-2022-248879.
Hürthle cell carcinoma (HCC) and medullary thyroid carcinomas (MTC) are uncommon histological subtypes of thyroid cancers, each accounting for around 3% of all thyroid cancers. A septuagenarian woman with a history of multiple primary cancer diagnoses presented with a growing left-sided neck lump. A diagnostic left thyroid lobectomy was performed, and pathological examination found two separate malignant foci: one HCC and an MTC. The patient developed left-sided HCC nodal metastasis, and following several multidisciplinary team discussions, a right completion lobectomy with left lateral neck dissection was performed, revealing further intrathyroidal MTC and extranodal extension of HCC. We present this as the first reported case of a collision tumour of HCC and MTC, and review the available literature regarding collision tumours and their management.
Hurthle 细胞癌 (HCC) 和甲状腺髓样癌 (MTC) 是甲状腺癌中罕见的组织学亚型，每种类型约占所有甲状腺癌的 3%。一位 70 岁的女性，有多种原发性癌症的诊断史，出现了左侧颈部肿块逐渐增大的情况。进行了诊断性左侧甲状腺叶切除术，病理检查发现两个独立的恶性病灶：一个 HCC 和一个 MTC。患者发生了左侧 HCC 淋巴结转移，经过多次多学科团队讨论，进行了右侧全甲状腺叶切除术和左侧颈侧区淋巴结清扫术，发现了更多的甲状腺内 MTC 和 HCC 的淋巴结外侵犯。我们提出了这是 HCC 和 MTC 碰撞瘤的首例报道，并回顾了关于碰撞瘤及其治疗的现有文献。
